Name: 專訪亞歷山大．梅巴扎教授！ (Interview with Professor Alexandre Mebazaa)
Uploaded: 2026-03-06T09:55:49.000Z
Duration: 9 min 34 s

I am a professor of critical care in the University of Paris.

我是巴黎大學嚴重照護的教授。

過去簡單式

I started research in cardiovascular area since many years.

我從很多年前就開始在心血管領域做研究。

動名詞

And very quickly it appears that biomarkers is a novel area and very exciting area, because we could try to assess the function of some organs by measuring the biomarkers upstream or downstream those organs and these five to 10 years ago, we started to work on biomarkers.

而且很快就發現生物標記是一個新穎且令人興奮的領域，因為我們可以透過測量器官上游或下游的生物標記來評估某些器官的功能，這五到十年前，我們就開始研究生物標記了。

And what is very exciting now is that we are discovering that among the biomarkers, some have no biological activities, those have a biological activity.

現在令人興奮的是，我們發現生物標記中有些沒有生物活性，有些則有生物活性。

And what is very, very exciting is that the biomarkers with the biological activity, we can try to modulate their activity.

而更有趣的是，具有生物活性的生物標記，我們可以嘗試調節牠們的活性。

Then we are moving from biomarker to bio targets.

所以我們正從生物標記轉向生物標靶。

This is a little bit in the cardiovascular area and in the acute critical care area.

這在心血管領域和急性嚴重照護領域都有一些。

And I'm putting a lot of efforts to have all the young fellows, young residents coming to our research group to learn what is research biomarkers of the future came because many people in my group, many people, part of our international collaborations, together with me, we discovered that indeed we are very expert in cardiovascular area.

我正努力讓所有年輕的研究員、年輕的住院醫師加入我們研究團隊，學習什麼是未來的生物標記研究，因為我團隊裡的許多人，我們國際合作的許多人，和我一起發現，我們確實是心血管領域的專家。

We are very expert in the critical care, but

我們在嚴重照護領域非常專精，但是

we discovered that people from other areas are doing excellent research in cancer and infectious disease.

我們發現其他領域的人在癌症和傳染病方面做了很棒的研究。

And there are new tools that are coming that are maybe more developed in some research area and others in other research area.

而且有一些新的工具即將問世，有些在某些研究領域發展得比較好，有些在其他研究領域。

And we thought that we need really to learn from each other.

所以我們覺得我們真的需要互相學習。

And this reason why we put together this conference and we asked the senior people who are doing those research to come and tell all of us what is really new.

這也是為什麼我們舉辦這次會議，並邀請那些做這些研究的資深人士來告訴我們所有最新的進展。

But maybe as importantly, during this biomarker of the future, it's also the room for very, very young fellows who are just doing their first research and who are successful in this research and biomarker to come and to present their last work.

但或許同樣重要的是，在這個未來生物標記的場合，也為那些剛開始做研究並在這方面有所成功的年輕研究員們，提供一個發表他們最新研究的機會。

And this competition was already a success since a few years.

這個競賽幾年前就已經很成功了。

And this year already is also a big success with a very large number of abstracts.

今年也已經非常成功，收到了大量的摘要。

Again, this biomarker of the future is the meeting of the senior researcher, but

再說一次，這個未來生物標記的會議，是資深研究人員的交流，但是

also the young researcher, the competition, we started it on the first biomarker event.

而且年輕研究員的競賽，是我們在第一次生物標記活動時就開始辦的。

這個競賽是由 Olink 贊助和支持的。

And when we had a discussion with Olink, they immediately understood that showing data from the young researcher, having the young researchers coming to this meeting is important.

當我們跟 Olink 討論時，他們立刻就明白，展示年輕研究員的數據，讓年輕研究員來參加這個會議是很重要的。

And now everybody is convinced that we were right to do so.

現在大家也都相信我們當初的決定是正確的。

This year we have a very large number of abstracts with a very high quality.

今年我們收到了非常多且品質很高的摘要。

Now, indeed, we couldn't listen to all the research that was sent to us.

現在，確實，我們無法聽完所有送來的研究。

We will shortlist it and we have already shortlisted 10 fellows and really bravo to those 10 fellows.

我們會篩選，而且我們已經篩選出了 10 位年輕研究員，真的要為這 10 位年輕研究員鼓掌。

Now they have to work, they have to have a great presentation.

現在他們必須努力，必須有一個很棒的報告。

They have also to answer to the questions.

The jury is a tough jury, it's an international jury.

評審團很嚴格，是一個國際評審團。

But this jury is going to be very nice with those 10 fellows and we'll be happy to see really brand new research and really for the young fellows, it's an incredible opportunity to be visible, to interact and many of those fellows become friends and many of the fellows who are participating to this contest and won the prizes have usually a great publication.

不過，這個評審團對這 10 位年輕研究員會很友善，我們也很高興能看到真正嶄新的研究，對這些年輕研究員來說，這是一個絕佳的機會讓自己被看見、與人交流，而且許多年輕研究員都變成了朋友，許多參加這場競賽並獲獎的研究員，通常都會有很棒的發表。

Then really, I really advise all the young researchers to attend, to listen to this competition and even make their choice and also participate with this competition in the following years.

所以，我真的建議所有年輕研究員都要來參加、來聽這場競賽，甚至做出自己的選擇，並且在未來的幾年也來參加這場競賽。

In my research we are using different tools and indeed we are using also proteomics.

在我的研究中，我們使用不同的工具，而且我們也使用質譜學。

And what is really great, using proteomics, is it open your eyes.

而質譜學真正棒的地方，就是它能讓你開闊眼界。

In other specialties and in a recent research that is ongoing right now, by using proteomics, we discovered that immunological path was altered.

在其他專科領域，以及目前正在進行的一項近期研究中，透過使用質譜學，我們發現免疫路徑被改變了。

And then I went to see experts in that area and we interacted.

然後我就去找該領域的專家，我們進行了交流。

They were happy, we were happy and we learned a lot.

他們很開心，我們也很開心，而且我們學到了很多。

Proteomic means putting several specialties together, having several specialties, talking to each other, but

質譜學意味著將多個專科領域結合在一起，讓多個專科領域互相交流，但是

having also engineers and biostatisticians who are coming and also bringing their expertise.

還有工程師和生物統計學家也加入，並帶來他們的專業知識。

And it's really an incredible opportunity to learn many new things, but also to interact with many specialties.

這真的是一個學習新事物，並與許多不同領域交流的絕佳機會。

Proteomic will bring a lot to the health care community first because it's going to help us showing novelties for many years.

質譜學將首先為醫療保健界帶來許多貢獻，因為它將幫助我們展現多年的新發現。

We're thinking research and medicine as a silo, that disease is a cardiovascular disease, that disease is a kidney disease.

我們將研究和醫學視為孤立的，認為疾病是心血管疾病，是腎臟疾病。

And we know today that this is not true, that there are common paths that make several organs sick and with altered function.

而我們今天知道這是不對的，有很多共同的路徑會讓多個器官生病且功能改變。

And proteomics is going not only to show how wide is the alteration, how many organs are altered, how many paths are altered, but

質譜學不僅會顯示改變的範圍有多大、有多少器官改變、有多少路徑改變，而且

also show the balance between maybe that organs that is more altered than in others, and

還會顯示器官之間可能存在的平衡，有些器官比其他器官改變得更多，而且

maybe more importantly it shows the benefits of the drugs.

或許更重要的是，它顯示了藥物的益處。

We have a recent study that we are finishing to study where we showed that a drug that has a beneficial effect for years, we are thinking that the effect is related to vascular disease and we are discovering that it's also having some benefits on coagulation and inflammation.

我們有一項最近完成的研究，我們發現一種有多年益處的藥物，我們原本認為其效果與心血管疾病有關，但我們發現它對凝血和發炎也有一些益處。

Then you see, proteomics is giving you really a wider picture, probably a more correct picture on.

所以你看，質譜學為你提供了更廣闊的視野，可能是更正確的視野。

When I started as a resident in intensive care medicine.

我剛開始在加護病房擔任住院醫師時。

My senior physicians were often telling me, okay, you do that medication for that disease and you do not do that medication to the other disease.

我的資深醫師常告訴我，好的，你用這個藥治療這個疾病，但不要用那個藥治療另一個疾病。

And I was always asking why and how come?

而我總是問為什麼，怎麼會這樣？

And sometimes the answer was a clear answer based on data and, and

有時候答案是有數據支持的明確答案，而且

many times in intensive care area the answer was we don't know.

在嚴重照護領域，很多時候的答案是我們不知道。

And this reason why I thought that I need really to go to research to try to understand step by step things to try to understand disease, try to understand therapies, try to use our patients and put them in a network to see that in fact there is a huge community all around the world having the same target, the same aim, which is to treat patients.

這也是我認為我真的需要投入研究，一步一步去理解事物、理解疾病、理解療法，並將我們的病患納入一個網絡，看看事實上全世界都有一個龐大的社群，擁有相同的目標，那就是治療病患。

And as you know, in intensive care we have a the mortality rate is very high in our beds.

而你所知道的，在嚴重照護領域，我們的病床死亡率非常高。

And then it's an everyday fight to try to make those patients surviving, even those patients having a great quality of life when they go out.

是以，每天都在努力讓這些病患存活下來，甚至讓那些病患在出院後也能有很好的生活品質。

And the only way to have those patients surviving is to understand the disease.

而要讓這些病患活下來，唯一的辦法就是了解疾病。

And what is really also great by doing research is in our research group, for instance, we have many residents, many fellows coming from all around the world.

而且做研究很棒的一點是，以我們研究團隊為例，我們有很多住院醫師、很多來自世界各地的年輕研究員。

In my lab right now, we have fellows from Japan, we used to have fellow from Finland, from Turkey, from Spain, all on the same lab, talking together.

在我目前的實驗室裡，有來自日本的研究員，以前還有來自芬蘭、土耳其、西班牙的研究員，大家都在同一個實驗室裡，一起交流。

And this is going to be the next generation of researcher and of clinicians.

而這將會是下一代的年輕研究員和臨床醫師。

And this is something that you see only when you are doing research, because everybody is motivated by the same thing as try to save patients lives and try to improve their quality of life.

這也是你只有在做研究時才會看到的情景，因為大家都有相同的目標，那就是努力拯救病患的生命，並改善他們的生活品質。