Name: 細胞的祕密語言——以及如何「解讀」它｜Chris Bahl｜TED (The Secret Language of Cells — and How to “Speak” It | Chris Bahl | TED)
Uploaded: 2025-11-30T09:28:51.000Z
Duration: 3 min 40 s

程度副詞

Most of the medicines that we use to treat diseases today work by interacting with just one type of protein in the body at a time.

我們現今用來治療疾病的大部分藥物，作用方式都是一次只與身體裡一種蛋白質互動。

But our cells communicate with one another using a complex language that involves many different types of proteins, all interacting with each other.

但我們的細胞彼此溝通，是使用一種複雜的語言，裡面有許多不同類型的蛋白質，而且它們都會互相作用。

情態副詞

This means that modern medicines, while amazing, are the linguistic equivalent to only knowing a single word.

這表示現代的藥物雖然很厲害，但語言學上來說，就像只知道一個單字一樣。

My team and I at AI Proteins are focused on becoming fluent in the language of cells and how cells talk to one another, and

我在AI Proteins的團隊致力於精通細胞的語言，以及細胞是如何互相溝通，

unlocking the next generation of medicines that are safer and more effective.

並解鎖下一代的藥物，讓它們更安全、更有效。

We've developed a new type of protein that's better at communicating with cells.

我們開發了一種新型蛋白質，它在與細胞溝通方面表現更好。

These are peptides, 40 to 60amino acids long that fold into three dimensional shapes much like a protein does.

這些是胜肽，長度約在 40 到 60 個胺基酸之間，它們會摺疊成三維形狀，就像蛋白質一樣。

And those typically have hundreds of amino acids.

而那些蛋白質通常有數百個胺基酸。

And all of the proteins that our bodies naturally produce are built from a common amino acid Alphabet.

我們身體自然產生的所有蛋白質，都是由一個共同的胺基酸字母表所建構的。

We use the same Alphabet for our mini proteins because we want them to be as safe as possible.

我們使用相同的字母表來製作我們的 miniproteins，因為我們希望它們盡可能安全。

Using generative artificial intelligence, we design our mini proteins from scratch.

我們利用生成式人工智慧，從頭開始設計我們的 miniproteins。

And this allows us to control everything about them.

這讓我們能夠控制它們的一切。

We design them to be small because this helps them to get around inside the body.

我們將它們設計得很小，因為這有助於它們在體內移動。

This simplifies manufacturing and administration to patients, but

這簡化了製造和給藥給病人的流程，但是

not too stable because we still want the body to be able to digest them after the job is done.

不能太穩定，因為我們還是希望身體在完成任務後能夠消化它們。

Most importantly, we design many proteins so that we can link them together.

最重要的是，我們設計了許多蛋白質，以便將它們連接在一起。

This is necessary to communicate with cells in a more sophisticated way.

這是以更複雜的方式與細胞溝通所必需的。

When you speak a language, you don't just know the words, you know grammar so that you can write phrases that provide cogent instructions.

當你說一種語言時，你不僅知道單字，還知道文法，這樣你就可以寫出提供連貫指令的短語。

For example, we can now talk with a particular type of immune cell.

舉個例子，我們現在可以跟特定類型的免疫細胞對話。

We can call to them by name and we can tell them to go out and attack cancer and provide context and logic for how this action should be carried out.

我們可以直接呼喚它們的名字，並告訴它們出去攻擊癌細胞，同時提供執行這項任務的背景資訊和邏輯。

Like leave normal healthy tissue alone while you're doing it.

像是執行任務時，要避開正常的健康組織。

We've shown the power of mini proteins by taking mice, giving them arthritis and treating their joint inflammation.

我們透過實驗，展示了微型蛋白質的威力：讓小鼠罹患關節炎，並治療牠們的關節發炎。

We've taken diabetic mice and used mini protein medicines to control blood glucose levels.

我們讓罹患糖尿病的小鼠，使用微型蛋白質藥物來控制血糖水準。

We've implanted mice with leukemia tumors and used human immune cells to treat them along with a mini protein that told them what to do.

我們在罹患白血病腫瘤的小鼠身上植入腫瘤，並使用人類免疫細胞，搭配微型蛋白質來治療，告訴它們該怎麼做。

There are many more diseases that we've treated in a test tube using mini proteins that we designed.

我們還在試管中，使用我們設計的微型蛋白質，治療了許多其他疾病。

The next step is to bring this technology and our pipeline of transformative new medicines to patients.

下一步是將這項技術和我們轉化性新藥的管線，帶給病患。

We announced the first mini Protein Pharma partnership last year with Bristol Myers Squibbling to create four new medicines separately.

我們去年宣佈了第一個微型蛋白質製藥合作夥伴關係，與 Bristol Myers Squibbling 攜手合作，共同開發四種新藥。

Our first clinical trial is planned to begin in 2028 with the goal of helping patients suffering from lung cancer.

我們第一個臨床試驗預計在 2028 年開始，目標是幫助肺癌患者。

Mini proteins enable a fundamentally new way of thinking about medicine and I am very excited by all that is possible now that we have the ability to speak fluently with our cells.

微型蛋白質讓我們能以一種全新的方式思考醫學，現在我們能與細胞流暢溝通，我對所有可能性感到非常興奮。