Name: 如果從老嬰兒開始出生，會怎麼樣？！ (What If You Started as an Old Baby?)
Uploaded: 2026-01-26T17:17:20.000Z
Duration: 5 min 26 s

基礎被動語態

We're very excited to say that this video is sponsored by Nautilus.

我們很興奮地跟大家說，這支影片是由 Nautilus 贊助的。

If you love learning and art, just like Life Noggin does, stay tuned at the end of the video to hear more about the cool work done by Nautilus and how viewers of Life Noggin can save Big.

如果你跟 Life Noggin 一樣，熱愛學習和藝術，那影片最後一定要繼續看下去，瞭解 Nautilus 的精彩工作，以及 Life Noggin 的觀眾可以如何省下大筆費用。

程度副詞

Dear Blocko, I just watched Benjamin Button with my grandma and I'm curious if that's real, but

親愛的 Blocko，我剛跟奶奶一起看了班傑明巴頓，我很好奇那是不是真的，但是

好的 Ryan，我會回答這個問題。

Oh, before I forget, Ryan, tell your grandma she makes the best cookies.

對了，差點忘了，Ryan，跟你阿嬤說她做的餅乾超好吃。

Scott Fitzgerald wrote a short story titled the Curious Case of Benjamin Button, who was born an old man and aged backwards throughout his life, eventually becoming an infant and then nothing.

Scott Fitzgerald 寫了一篇短篇小說，叫做《班傑明·巴頓奇事》，故事主角出生時是個老人，然後人生一路逆向老化，最後變成嬰兒，然後消失。

But the actual disease that this story is based on doesn't really work like that.

但其實這個故事靈感來源的真實疾病，並不是這樣運作的。

It's called Hutchinson's Guilford progeria syndrome, or HGPS, and it was first documented in 1886.

它叫做 Hutchinson's Guilford progeria syndrome，簡稱 HGPS，最早在1886年被記錄下來。

It occurs in 1 out of every 4 million babies.

大約每400萬個新生兒中，會有1個得到。

But instead of being born as an elderly person and aging backwards, those with HGPS are born normally, but

不過，HGPS 患者並不是出生時就顯老然後逆向老化，他們出生時是正常的，但是

會以驚人的速度老化，並且早逝。

These children start to show signs of the disease in their first year of life.

這些孩子在出生第一年就會開始出現疾病的跡象。

Symptoms include slowed growth, a larger head and eyes, a smaller jaw, a thin nose, wrinkled skin, hair loss, and

症狀包括生長遲緩、頭部和眼睛較大、下巴較小、鼻子較尖、皮膚皺紋、掉髮，以及

As they get older, they begin to experience health issues typically of a 50 year old, like bone loss, cataracts, arthritis, hardening of the arteries, and

隨著年齡增長，他們會開始出現一般50歲才會有的健康問題，像是骨質流失、白內障、關節炎、動脈硬化，以及

They usually die of a heart attack or stroke.

他們通常死於心臟病發作或中風。

The condition is always fatal, with an average lifespan of just 13 years.

這種疾病總是致命的，平均壽命只有13歲。

There are a couple of related diseases that fall under the progeria umbrella of rapid aging.

有幾種相關的疾病也屬於早衰症這個快速老化傘下的範疇。

Wiedermann Rothenstrau Syndrome appears in babies before they're born, and

Wiedermann Rothenstrau Syndrome 在嬰兒出生前就會出現，而

the symptoms of Werner Syndrome normally occur in teenagers.

Werner Syndrome 的症狀通常發生在青少年時期。

HGPS is caused by a genetic mutation in the Lamin A or LMNA gene.

HGPS 是由 Lamin A 或 LMNA 基因的基因突變所引起。

This gene makes the lamin A protein which has an incredibly important job.

這個基因會製造層黏蛋白 A（lamin A）蛋白質，它有個非常重要的功能。

It holds the nucleus in each of your cel cells together, but with just a tiny mutation.

它能將你每個細胞的細胞核固定在一起，但只要有微小的突變。

The LMNA gene in those with HGPS instead makes an abnormal form of the protein called progerin.

HGPS 患者的 LMNA 基因則會製造一種異常形式的蛋白質，稱為早衰蛋白（progerin）。

This makes the cells unstable, slowly damaging them until they die early, which causes premature aging.

這會讓細胞變得不穩定，慢慢損壞它們直到提早死亡，造成早發性老化。

This mutation happens randomly in the sperm cell, meaning it's not a disease that you inherit from your parents.

這個突變是隨機發生在精子細胞中，這表示這不是一種你會從父母那裡遺傳到的疾病。

While there's no cure, the cancer drug Lonafernib has been found to improve symptoms and increase the average survival rate by 2.

雖然目前沒有治癒方法，但抗癌藥物 Lonafernib 被發現可以改善症狀並將平均存活率提高 2 年。

It was approved by the US FDA in 2020 to treat HGPS, and

它在 2020 年獲得美國FDA核准用於治療 HGPS，而且

it's the first treatment for this disease.

這是這種疾病的第一種治療方法。

It works by preventing an important chemical process that lamin A and progerin need in order to function.

它的作用是阻止層黏蛋白 A 和早衰蛋白運作所需的一個重要化學過程。

Without that, patients experienced weight gain, improved bone structure, and reduced arterial stiffness.

沒有了這個過程，病患會經歷體重增加、骨骼結構改善，以及動脈僵硬度降低。

Scientists are still looking for even more effective therapies and ways to improve the lives of those affected with hgps.

科學家們仍在尋找更有效的療法，以及改善受 HGPS 影響者生活的方法。

And as scientists continue to embark on this quest, the you can support further research by visiting the links in the description.

而且，隨著科學家們繼續這項探索，你也可以透過點擊說明欄中的連結來支持進一步的研究。

Let me know in the comment section below any disease or condition that you want me to cover.

在下方的留言區告訴我，你希望我介紹哪些疾病或病症。

Next, I might turn it into a future Life Noggin episode like this one.

接下來，我可能會將它做成一集未來的 Life Noggin 節目，就像這一集一樣。

Anyone who sees the value in using visuals or a unique idea to help people learn is a friend of Life Noggin.

任何認同透過視覺化或獨特想法來幫助人們學習價值的人，都是 Life Noggin 的朋友。

That's why I was, I guess you could say overly excited when I got the chance to work with today's sponsor, Nautilus.

這就是為什麼當我有機會與今天的贊助商 Nautilus 合作時，我感到非常興奮。

If you're looking to shake up how you learn about the world beyond just YouTube, check this out.

如果你想讓學習世界的管道不只侷限於 YouTube，不妨看看這個。

Nautilus explores big ideas in science and its stories present ideas that will be debated long into the future and as a result has established itself as the foremost literary science magazine.

Nautilus 探索科學上的重大想法，其故事呈現了未來將被廣泛討論的觀點，是以已成為首屈一指的文學科學雜誌。

You can join as a digital only member or print to receive six beautifully illustrated, award winning collectible editions that are a staple of any respectable home library.

你可以成為數位會員或印刷會員，每季收到六本精美插畫、獲獎的收藏版雜誌，這也是任何體面家庭圖書館的必備品。

One of my favorite parts is that in addition to full access to all the stories in Nautilus, members receive benefits like priority access to events, exclusive products and product discounts.

我最喜歡的部分之一是，除了能完整閱讀 Nautilus 的所有文章外，會員還能享有優先參加活動、獨家產品和產品折扣等福利。

For example, Nautilus recently produced a line of ocean science inspired merch with Australian streetwear company Jungles.

舉例來說，Nautilus 最近和澳洲街頭服飾品牌 Jungles 合作推出了一系列以海洋科學為靈感的周邊商品。

Quotes for the collection were provided by Roger Payne, the legendary biologist and environmentalist who discovered and first recorded humpback whale songs in 1967.

這系列商品的引言，來自傳奇生物學家兼環保人士 Roger Payne，他於 1967 年發現並首次錄製了座頭鯨的歌聲。

All proceeds were donated to Nautilus Ocean Conservation Fund.

所有收益都捐給了 Nautilus Ocean Conservation Fund。

It's this merger of art, culture, science and discovery that make Nautilus stand apart from the traditional science news sources.

正是這種藝術、文化、科學和探索的結合，讓 Nautilus 在傳統科學新聞來源中脫穎而出。

Memberships to Nautilus rarely go on sale, but

Nautilus 的會員資格很少打折，但是

you can go to this link right here to receive 15% off your membership today.

你現在可以到這個連結，享有會員資格 15% 的折扣。

Use our code Life Noggin to unlock the offer or click the first link in the description and treat yourself to more fun ways to learn.

使用我們的 Life Noggin 代碼來解鎖優惠，或是點擊說明中的第一個連結，好好犒賞自己，用更有趣的方式學習。

Click here to figure out which age is the worst or click here to watch this video.

點這裡看看哪個年齡最糟糕，或是點這裡觀看這個影片。

Thank you so much to Lifespan IO, the team that powers Life Noggin.

非常感謝 Lifespan IO，也就是 Life Noggin 的團隊。

Check them out right now down in the description.