Name: 關於微劑量的最大謊言 (The Biggest Lie About Microdosing)
Uploaded: 2025-07-21T17:59:37.000Z
Duration: 5 min 53 s

Whether it's microdosing.com, thousands of online articles touting microdosing's positive effects, or the fact that microdosing is now a multi-billion dollar industry, taking small amounts of psychedelics is now the it thing to do.

無論是 microdosing.com，還是成千上萬篇吹捧微量吸食的積極效果的網絡文章，抑或是微量吸食如今已成為價值數十億美元的產業這一事實，吸食少量迷幻劑如今已成為一種潮流。

While you can technically microdose any drugs, microdosing psychedelics like magic mushrooms and LSD are where most of these positive claims are coming from.

雖然從技術上講，你可以微量服用任何藥物，但微量服用迷幻劑（如神奇蘑菇和迷幻劑）是這些正面說法的主要來源。

But the scientific results of microdosing are only really coming in now.

但是，微劑量的科學成果現在才真正問世。

So is microdosing actually one of the biggest scams of the 2020s?

那麼，微劑量是否真的是 2020 年代最大的騙局之一？

Let's take the popular microdosing drug magic mushrooms containing the active ingredient psilocybin.

以流行的微劑量藥物魔幻蘑菇為例，其中含有活性成分迷幻蘑菇素。

When ingested, the psilocybin is rapidly dephosphorylated under the acidic environment of the stomach or by alkaline phosphatase in the intestine, kidney, and even the blood.

攝入後，在胃的酸性環境下，或在腸道、腎臟甚至血液中的鹼性磷酸酶作用下，迷幻藥會迅速去磷酸化。

The biochemical reaction generates a phenol compound called psilocin.

這種生化反應會產生一種名為 "茜洛辛 "的苯酚化合物。

This is the active compound that can easily cross the blood brain barrier and get you high.

這是一種活性化合物，能輕易穿過血腦屏障，讓人興奮。

If you have taken a recreational dose as high as 2000 milligrams, the active psilocin causes the body to experience visual and auditory hallucinations, heightened senses, and emotional sensitivity.

如果您服用的娛樂劑量高達 2000 毫克，那麼活性西洛辛會使人體產生視覺和聽覺幻覺、感官增強和情緒敏感。

These feelings usually last three to eight hours and it is thought that the effects are mediated by the fact that the drug prevents the reuptake of the neurotransmitter serotonin in the brain and also has a similar chemical structure to serotonin, meaning it can also bind to receptors in your brain.

這種感覺通常會持續 3 到 8 個小時，據認為，產生這種效果的原因是，這種藥物會阻止大腦對神經遞質血清素的再攝取，而且其化學結構與血清素相似，這意味著它也能與大腦中的受體結合。

New information on how psychedelics work add to these ideas and think that psilocin can cross cellular membranes, bind intracellularly to specific proteins which cause neuroplastic effects, essentially making your brain work in new ways.

關於迷幻藥如何發揮作用的新資訊補充了這些觀點，認為迷幻藥可以穿過細胞膜，在細胞內與特定蛋白質結合，從而產生神經可塑效應，本質上就是讓大腦以新的方式工作。

Either way, it causes your brain to biologically perceive and experience things without a real stimulus, also known as hallucinating.

無論哪種方式，它都會讓你的大腦在沒有真實刺激的情況下產生生物感知和體驗，也就是所謂的幻覺。

Now, there is some pretty exciting research showing that this altered consciousness created by a recreational dose of psilocybin could help with symptoms of major depressive disorder.

現在，一些非常令人興奮的研究表明，通過娛樂性服用迷幻藥而產生的意識改變可以幫助緩解重度抑鬱症狀。

There are also other promising studies explaining how the drug's ability to alter your brain activity could help neurological connections in the brain that could mitigate the effects of anxiety disorders, depressive disorders, and attention deficit disorder.

還有其他一些前景看好的研究解釋了這種藥物改變大腦活動的能力如何幫助大腦神經連接，從而減輕焦慮症、抑鬱症和注意力缺陷障礙的影響。

As well, full doses of LSD might have anti-inflammatory properties that are related to depression and could help with depression.

此外，全劑量的迷幻藥可能具有與抑鬱症有關的抗炎特性，可以幫助治療抑鬱症。

But these studies are not about microdosing.

These studies involve full doses of the drug.

Microdosing means you take 110th to 120th the recreational dose.

微劑量是指服用娛樂劑量的 110 至 120 倍。

So instead of taking 2,000 milligrams, you're taking between 100 to 200 milligrams and most often once every three days, keeping the doses low enough that you don't feel any of the physiological alterations of consciousness from the recreational dose, but still get the psychological benefits of regular use.

是以，你需要服用的劑量不是 2,000 毫克，而是 100 至 200 毫克，最常見的是每三天服用一次，保持足夠低的劑量，這樣你就不會從娛樂劑量中感受到任何生理上的意識改變，但仍能獲得定期服用帶來的心理益處。

Microdosing advocates, products, and websites have claims of increased productivity, creativity, social ability, better sex lives, increased focus, positive mood, increased mindfulness, and a better general wellbeing.

微劑量的倡導者、產品和網站都聲稱，微劑量可以提高生產力、創造力、社交能力、更好的性生活、更集中的注意力、積極的情緒、更敏銳的思維以及更好的整體健康。

But I hate to say it, a lot of the new scientific research is coming in saying that these companies might be lying to you.

但我不想這麼說，很多新的科學研究表明，這些公司可能在騙你。

To start, one of the biggest issues is that the claims from these microdosing websites and advocates are too broad to study.

首先，最大的問題之一是這些微劑量網站和倡導者的說法過於寬泛，難以研究。

The claims are so wide ranging that it leads to too many variables when trying to create a scientific study that can stand up to scrutiny.

這些說法涉及面太廣，導致在試圖進行一項經得起推敲的科學研究時出現太多變數。

Claiming that microdosing will make you more productive, creative, have better sex, or just enjoy life more is extremely broad and not usually how drugs work.

聲稱使用微劑量會讓你更有效率、更有創造力、有更好的性生活，或者只是更享受生活，這種說法非常寬泛，而且通常不是藥物的作用方式。

But these broad positive claims from advocates or websites actually lead to the biggest problem with microdosing right now, which is that in double blind controlled studies, microdosing doesn't perform any better than a placebo.

但是，這些來自倡導者或網站的廣泛正面說法實際上導致了目前微劑量最大的問題，那就是在雙盲對照研究中，微劑量的表現並不比安慰劑好。

One double blind controlled study examined the effects of four LSD microdoses on people aged 18 to 35.

一項雙盲對照研究考察了四次微劑量迷幻劑對 18 至 35 歲人群的影響。

One group was given a microdose of 13 micrograms, another given double that at 26 micrograms, and a third group given a placebo.

其中一組的微量劑量為 13 微克，另一組為雙倍劑量 26 微克，第三組為安慰劑。

The participants were asked mood questionnaires for five hours after each dose and completed cognitive and behavioral tests after the first and final doses.

每次用藥後的五個小時內，參與者都要接受情緒問卷調查，並在第一次和最後一次用藥後完成認知和行為測試。

There were no significant differences between the three groups.

Those who were microdosing and those who got placebos but thought they were microdosing felt the same.

那些服用了微劑量的人和那些服用了安慰劑但認為自己服用了微劑量的人感覺是一樣的。

Another study on 191 participants who gave themselves microdoses of either the real thing or a placebo, they didn't know which they got, but they did administer the pills themselves at home, found that in all cases, they had improved psychological outcomes significantly from the baseline, but there was no significant difference between the people taking a real microdose or those taking a placebo.

另一項研究對 191 名參與者進行了研究，他們給自己注射了微劑量的真藥或安慰劑（他們不知道自己吃的是哪一種，但他們確實在家裡自己服用了藥片），結果發現，在所有情況下，他們的心理結果都比基線有顯著改善，但服用真藥或安慰劑的人之間沒有顯著差異。

The researcher actually said as the results came in, when we started this study, our vision was that we'll be the heroes to prove that microdosing works.

實際上，研究人員在結果出來後說，當我們開始這項研究時，我們的願景是，我們將成為證明微量給藥有效的英雄。

The microdosing community was pretty bummed out.

Another study found that there were changes in brain activity in those who were microdosing psilocybin, but it was not a double-blind placebo test.

另一項研究發現，服用微量迷幻藥的人的大腦活動發生了變化，但這並不是一項雙盲安慰劑試驗。

They were aware that they were microdosing.

他們知道自己在服用微量藥物。

And although there was altered EEG rhythms, there was no evidence to support enhanced wellbeing, creativity, or cognitive function.

雖然腦電圖節律發生了改變，但沒有證據表明健康、創造力或認知功能得到了增強。

And the understanding was that expectation underlied the anecdotal benefits attributed to microdosing.

而人們的理解是，這種期望是微量給藥的軼事好處的基礎。

Essentially, because people were expecting microdosing to work, it did, the same way a placebo works.

從根本上說，因為人們期待微劑量起作用，所以它確實起作用了，就像安慰劑起作用一樣。

This doesn't necessarily mean that microdosing isn't working, because there are amazing studies about how placebos work.

這並不一定意味著微量給藥不起作用，因為有很多關於安慰劑如何起作用的驚人研究。

Microdosing just might be a placebo, but the scientific community is starting to lose hope around the actual physiological mechanisms of microdosing and think that the popularity of microdosing has outpaced the research.

微量給藥可能只是一種安慰劑，但科學界開始對微量給藥的實際生理機制失去希望，認為微量給藥的普及速度已經超過了研究速度。

So many people I know microdose and have talked to me about it, so I find this information fascinating.

我認識的很多人都服用過微量劑量，也跟我聊過這個話題，所以我覺得這些資訊很吸引人。

I'm curious how the scientific literature will impact the industry, but right now it is a booming.

我很好奇科學文獻將如何影響這個行業，但現在這個行業正在蓬勃發展。

Thank you so much for watching this science video.

非常感謝您觀看這段科普視頻。

我們很快就會看到你的新作品。