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  • Hello, everyone. My name is Oh, Jae-Hoon, a PhD student of Department of Bio and Brain Engineering.

    哈摟,各位大家好。我叫Oh, Jae-Hoon,目前是生物與腦科學工程的博士班學生。

  • Today topic is that immune cell therapy for liver disease.

    今天主題是肝病之免疫細胞療法

  • Before a professor’s lecture, I will introduce some basic information of liver and liver disease.

    在教授的演講之前,我會先介紹有關於肝與肝病的資訊。

  • Liver is the largest organ of the body. Liver is a reddish brown organ with four lobes of

    肝是人體內最大器官。呈暗棕色且有四個不等規則區塊。

  • unequal size and shape. It is located in the right side of the abdominal cavity under the diaphragm.

    它位於隔膜下的腹腔的右側。

  • Liver plays an important role in synthesis of proteins such as albumin, clotting factors and complements.

    肝臟扮演很重要角色,集結蛋白質,凝固因子和補充物質。

  • Liver is involved in detoxification and storage. In addition, it participates in the metabolism

    肝臟處理解毒和儲存肝醣。另外,肝臟參與代謝脂肪和碳水化合物的過程。

  • of lipids and carbohydrates. The liver is the only human organ regenerating lost tissue.

    肝是人類器官中唯一可以在缺損後再生的。

  • 25% of a liver can regenerate into a whole liver.

    只要25%肝臟組織,就能再生成全部的肝臟器官。

  • The liver gets dual blood supply from the hepatic arteries and hepatic portal vein.

    肝臟有雙重血管供應,來自於肝動脈和肝靜脈口

  • The liver is composed of hepatocyte, kuppfer cell, sinusoidal endothelial cell, hepatic stellate cell,and so on.

    肝臟包括肝細胞,庫佛氏細胞,肝竇內皮細胞,肝星狀細胞等

  • 80% of the liver volume is occupied by hepatocytes.

    80%肝臟被肝細胞佔據

  • Hepatocytes play a vital role of hepatic function. Sinusoidal endothelial cells make sinusoidal

    肝細胞扮演重要的肝臟功能。正弦內皮細胞產生正弦

  • blood vessel which serve as a way for the oxygen-rich blood from the hepatic artery

    血管,其用作來自肝動脈的富氧血液的途徑

  • and the nutrient-rich blood from the portal vein. Kupffer cells are located in the wall of sinusoids.

    和來自門靜脈的富營養血液。 庫佛氏細胞位於正弦波的壁上。

  • They act as macrophages. Hepatic stellate cells are found in the space between

    它們作為巨噬細胞。 肝星狀細胞存在於之間的空間

  • the sinusoids and hepatocytes. In normal liver, the function and role of hepatic stellate

    竇狀隙和肝細胞。 在正常肝,肝星狀的功能和作用

  • cells is unclear. Recent evidence suggests a role as an antigen-presenting cell.

    仍不清楚。 最近的證據顯示它能作為抗原,呈遞細胞。

  • When the liver is damaged, stellate cells can secrets extracellular matrix (collagen).

    當肝臟受損時,星狀細胞可分泌細胞外基質(膠原蛋白)。

  • There are many kinds of liver disease. The most widely spread liver diseases are fatty liver,

    有多種肝病。 最廣泛傳播的肝臟疾病是脂肪肝

  • hepatitis, cirrhosis and liver cancer. Fatty liver is a condition that fat accumulate in liver cells.

    肝炎,肝硬化和肝癌。 肝細胞是脂肪肝是脂肪蓄積的條件

  • Microscope shows the large vacuoles of fat in liver tissue.

    顯微鏡顯示肝組織中脂肪的大液泡。

  • Hepatitis is an inflammatory disease of the liver. Inflammation is caused by viruses,alcohol, toxin and so on.

    肝炎是肝臟的炎性疾病。 炎症是由病毒,酒精和毒素引起

  • Cirrhosis is chronic liver disease characterized by replacement

    肝硬化是以替換為特徵的慢性肝病

  • of healthy liver tissue by fibrosis, scar tissue. Liver cancers are malignant tumors

    的健康肝組織由纖維,瘢痕組織。 肝癌是惡性腫瘤 瘢痕

  • that grow on the surface or inside the liver. The most frequent liver cancer is hepatocellular carcinoma.

    生長在肝臟的表面或內部。 最常見的肝癌是肝細胞癌

  • It accounts for 75% of all liver cancers, Another type of cancer formed by

    它佔所有肝癌的75%,由另一種類型的癌症形成

  • liver cells is hepatoblastoma, which is formed by immature liver cells. It is a rare malignant

    肝細胞是肝母細胞瘤,其由未成熟肝細胞形成。 它是一種罕見的惡性腫瘤

  • tumor that develops in children.

    在發育中的兒童

  • I’ll explain cirrhosis in more details. Cirrhosis is mostly caused by alcoholism,

    我將解釋肝硬化疾病相關個案。肝硬化主要是由酒精中毒,

  • hepatitis virus, autoimmune, drug, and fatty liver which induce liver injury.

    肝炎病毒,自身免疫,藥物和引起肝損傷的脂肪肝。

  • In response to liver injury, extracellular matrix or scar is accumulated. This process is called fibrosis.

    肝損傷反應,細胞外基質或瘢痕被積累。 這個過程稱為纖維化。

  • Accumulation of extracellular matrix is considered as wound healing process.

    細胞外基質的積累被認為是傷口癒合過程。

  • However If liver is damaged by long-term injury, scar tissue by fibrosis replaces healthy tissue.

    然而,如果肝臟受到長期損傷,瘢痕組織會通過纖維替代健康組織。

  • Over time this process results in cirrhosis of the liver. Scar tissue of cirrhosis is

    隨著時間的推移,該過程導致肝硬化。 肝硬化的瘢痕組織是

  • not able to do normal hepatic function. Once cirrhosis has developed, the serious complications

    不能做正常肝功能。 一旦肝硬化發展,嚴重的並發症

  • of liver disease may occur, including liver failure and liver cancer.

    的肝病可能發生,包括肝衰竭和肝癌。

  • What is the cellular mechanism of fibrosis? Liver injury activates hepatic stellate cells

    纖維化的細胞機制是什麼? 肝損傷激活肝星狀細胞

  • and Kuppfer cells. Stellate cell activation is a key pathogenic feature underlying liver

    和Kupffer細胞。 星狀細胞活化是肝臟下的關鍵致病特徵

  • fibrosis and cirrhosis. Activated hepatic stellate cells produce a huge amount of extracellular

    纖維化和肝硬化。 活化的肝星狀細胞產生大量的細胞外

  • matrix (collagen fibers) and many cytokine mediators (transforming growth factor-beta,

    基質(膠原纖維)和許多細胞因子介質(轉化生長因子-β,

  • interleukin-6 and monocyte chemoattractant protein-1). Interaction of hepatic stellate

    白細胞介素-6和單核細胞趨化蛋白-1)。 肝星狀相互作用和

  • cells and immune cells in liver is related in the progression of liver fibrosis.

    肝臟中的細胞和免疫細胞與肝纖維化的進展相關。

  • Some immune cells ameliorate liver fibrosis.

    一些免疫細胞改善肝纖維化。

  • What is the treatment for cirrhosis? Currently, cirrhosis can't be cured

    什麼是肝硬化的治療? 目前,肝硬化不能治愈。

  • However, it is possible to manage the symptoms and any complications, and slow its progression.

    然而,可以治療症狀和任何並發症,並減緩其進展。

  • Because cirrhosis is irreversible, treatment aims to stop the disease from getting worse.

    因為肝硬化是不可逆轉的,治療的目的是阻止這種疾病的惡化。

  • The treatment depends on the cause of cirrhosis. If cirrhosis is caused by viral hepatitis,

    治療取決於肝硬化的原因。 如果肝硬化是由病毒性肝炎引起的,

  • patients may be treated with anti-viral drugs. If the patients are heavy drinkers, they are

    患者可以用抗病毒藥物治療。 如果病人是重度飲酒者,他們是

  • advised to stop drinking alcohol. If the patients are overweight, they are advised to lose weight.

    建議停止飲酒。 如果患者超重,建議他們減重

  • If cirrhosis is very severe and the liver stops working, the only treatment option

    如果肝硬化非常嚴重,肝臟停止運轉,唯一的治療選擇

  • is liver transplantation.

    是肝移植。

  • There are many scientific efforts to develop new treatment methods for cirrhosis.

    有許多科學努力開發新的肝硬化治療方法。

  • Professor Jeong Won il (KAIST) and Kim Ja Kyoung (Yonsei University college of medicine ) have developed

    教授Jeong Won il(KAIST)和Kim Jae Kyung(延世大學醫學院)

  • new and novel treatment for liver cirrhosis. They used immune cell therapy.

    新的和新的治療肝硬化。 他們使用免疫細胞治療。

  • Autologous bone marrow cells were transplanted into the patients of cirrhosis.

    將自體骨髓細胞移植到肝硬化患者中。

  • Autologous bone marrow cells increase the production of cytokines which inhibited the hepatic stellate

    自體骨髓細胞增加抑制肝星狀細胞的細胞因子的產生

  • cells from secreting collagens. In this clinical trial, the immune cell therapy was effective

    細胞從分泌膠原。 在這個臨床試驗中,免疫細胞療法是有效的

  • to improve 70% of the cirrhosis patients.

    改善70%的肝硬化患者。

  • Today speaker is Professor Jeong won ill, at KAIST Graduate School of Medical Science and Engineering.

    今天的演講者是教授Jeong won ill,KAIST醫學科學和工程系的研究生

  • Prof. Jeong will give us a lecture on immune cell therapy for liver disease.

    Jeong教授將向我們講授肝臟免疫細胞治療

  • Thank you for listening.

    感謝您的聆聽

Hello, everyone. My name is Oh, Jae-Hoon, a PhD student of Department of Bio and Brain Engineering.

哈摟,各位大家好。我叫Oh, Jae-Hoon,目前是生物與腦科學工程的博士班學生。

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B2 中高級 中文 英國腔 細胞 肝臟 免疫 治療 因子 脂肪

研討系列]針對免疫反應的慢性肝病治療,介紹一下。 ([Seminar Series] Treatment of chronic liver disease targeting immune responses, introduction)

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    Study English 發佈於 2021 年 01 月 14 日
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