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  • Hello, everyone. My name is Oh, Jae-Hoon, a PhD student of Department of Bio and Brain Engineering.

    哈摟,各位大家好。我叫Oh, Jae-Hoon,目前是生物與腦科學工程的博士班學生。

  • Today topic is that immune cell therapy for liver disease.


  • Before a professor’s lecture, I will introduce some basic information of liver and liver disease.


  • Liver is the largest organ of the body. Liver is a reddish brown organ with four lobes of


  • unequal size and shape. It is located in the right side of the abdominal cavity under the diaphragm.


  • Liver plays an important role in synthesis of proteins such as albumin, clotting factors and complements.


  • Liver is involved in detoxification and storage. In addition, it participates in the metabolism


  • of lipids and carbohydrates. The liver is the only human organ regenerating lost tissue.


  • 25% of a liver can regenerate into a whole liver.


  • The liver gets dual blood supply from the hepatic arteries and hepatic portal vein.


  • The liver is composed of hepatocyte, kuppfer cell, sinusoidal endothelial cell, hepatic stellate cell,and so on.


  • 80% of the liver volume is occupied by hepatocytes.


  • Hepatocytes play a vital role of hepatic function. Sinusoidal endothelial cells make sinusoidal


  • blood vessel which serve as a way for the oxygen-rich blood from the hepatic artery


  • and the nutrient-rich blood from the portal vein. Kupffer cells are located in the wall of sinusoids.

    和來自門靜脈的富營養血液。 庫佛氏細胞位於正弦波的壁上。

  • They act as macrophages. Hepatic stellate cells are found in the space between

    它們作為巨噬細胞。 肝星狀細胞存在於之間的空間

  • the sinusoids and hepatocytes. In normal liver, the function and role of hepatic stellate

    竇狀隙和肝細胞。 在正常肝,肝星狀的功能和作用

  • cells is unclear. Recent evidence suggests a role as an antigen-presenting cell.

    仍不清楚。 最近的證據顯示它能作為抗原,呈遞細胞。

  • When the liver is damaged, stellate cells can secrets extracellular matrix (collagen).


  • There are many kinds of liver disease. The most widely spread liver diseases are fatty liver,

    有多種肝病。 最廣泛傳播的肝臟疾病是脂肪肝

  • hepatitis, cirrhosis and liver cancer. Fatty liver is a condition that fat accumulate in liver cells.

    肝炎,肝硬化和肝癌。 肝細胞是脂肪肝是脂肪蓄積的條件

  • Microscope shows the large vacuoles of fat in liver tissue.


  • Hepatitis is an inflammatory disease of the liver. Inflammation is caused by viruses,alcohol, toxin and so on.

    肝炎是肝臟的炎性疾病。 炎症是由病毒,酒精和毒素引起

  • Cirrhosis is chronic liver disease characterized by replacement


  • of healthy liver tissue by fibrosis, scar tissue. Liver cancers are malignant tumors

    的健康肝組織由纖維,瘢痕組織。 肝癌是惡性腫瘤 瘢痕

  • that grow on the surface or inside the liver. The most frequent liver cancer is hepatocellular carcinoma.

    生長在肝臟的表面或內部。 最常見的肝癌是肝細胞癌

  • It accounts for 75% of all liver cancers, Another type of cancer formed by


  • liver cells is hepatoblastoma, which is formed by immature liver cells. It is a rare malignant

    肝細胞是肝母細胞瘤,其由未成熟肝細胞形成。 它是一種罕見的惡性腫瘤

  • tumor that develops in children.


  • I’ll explain cirrhosis in more details. Cirrhosis is mostly caused by alcoholism,


  • hepatitis virus, autoimmune, drug, and fatty liver which induce liver injury.


  • In response to liver injury, extracellular matrix or scar is accumulated. This process is called fibrosis.

    肝損傷反應,細胞外基質或瘢痕被積累。 這個過程稱為纖維化。

  • Accumulation of extracellular matrix is considered as wound healing process.


  • However If liver is damaged by long-term injury, scar tissue by fibrosis replaces healthy tissue.


  • Over time this process results in cirrhosis of the liver. Scar tissue of cirrhosis is

    隨著時間的推移,該過程導致肝硬化。 肝硬化的瘢痕組織是

  • not able to do normal hepatic function. Once cirrhosis has developed, the serious complications

    不能做正常肝功能。 一旦肝硬化發展,嚴重的並發症

  • of liver disease may occur, including liver failure and liver cancer.


  • What is the cellular mechanism of fibrosis? Liver injury activates hepatic stellate cells

    纖維化的細胞機制是什麼? 肝損傷激活肝星狀細胞

  • and Kuppfer cells. Stellate cell activation is a key pathogenic feature underlying liver

    和Kupffer細胞。 星狀細胞活化是肝臟下的關鍵致病特徵

  • fibrosis and cirrhosis. Activated hepatic stellate cells produce a huge amount of extracellular

    纖維化和肝硬化。 活化的肝星狀細胞產生大量的細胞外

  • matrix (collagen fibers) and many cytokine mediators (transforming growth factor-beta,


  • interleukin-6 and monocyte chemoattractant protein-1). Interaction of hepatic stellate

    白細胞介素-6和單核細胞趨化蛋白-1)。 肝星狀相互作用和

  • cells and immune cells in liver is related in the progression of liver fibrosis.


  • Some immune cells ameliorate liver fibrosis.


  • What is the treatment for cirrhosis? Currently, cirrhosis can't be cured

    什麼是肝硬化的治療? 目前,肝硬化不能治愈。

  • However, it is possible to manage the symptoms and any complications, and slow its progression.


  • Because cirrhosis is irreversible, treatment aims to stop the disease from getting worse.


  • The treatment depends on the cause of cirrhosis. If cirrhosis is caused by viral hepatitis,

    治療取決於肝硬化的原因。 如果肝硬化是由病毒性肝炎引起的,

  • patients may be treated with anti-viral drugs. If the patients are heavy drinkers, they are

    患者可以用抗病毒藥物治療。 如果病人是重度飲酒者,他們是

  • advised to stop drinking alcohol. If the patients are overweight, they are advised to lose weight.

    建議停止飲酒。 如果患者超重,建議他們減重

  • If cirrhosis is very severe and the liver stops working, the only treatment option


  • is liver transplantation.


  • There are many scientific efforts to develop new treatment methods for cirrhosis.


  • Professor Jeong Won il (KAIST) and Kim Ja Kyoung (Yonsei University college of medicine ) have developed

    教授Jeong Won il(KAIST)和Kim Jae Kyung(延世大學醫學院)

  • new and novel treatment for liver cirrhosis. They used immune cell therapy.

    新的和新的治療肝硬化。 他們使用免疫細胞治療。

  • Autologous bone marrow cells were transplanted into the patients of cirrhosis.


  • Autologous bone marrow cells increase the production of cytokines which inhibited the hepatic stellate


  • cells from secreting collagens. In this clinical trial, the immune cell therapy was effective

    細胞從分泌膠原。 在這個臨床試驗中,免疫細胞療法是有效的

  • to improve 70% of the cirrhosis patients.


  • Today speaker is Professor Jeong won ill, at KAIST Graduate School of Medical Science and Engineering.

    今天的演講者是教授Jeong won ill,KAIST醫學科學和工程系的研究生

  • Prof. Jeong will give us a lecture on immune cell therapy for liver disease.


  • Thank you for listening.


Hello, everyone. My name is Oh, Jae-Hoon, a PhD student of Department of Bio and Brain Engineering.

哈摟,各位大家好。我叫Oh, Jae-Hoon,目前是生物與腦科學工程的博士班學生。


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B2 中高級 中文 英國腔 細胞 肝臟 免疫 治療 因子 脂肪

研討系列]針對免疫反應的慢性肝病治療,介紹一下。 ([Seminar Series] Treatment of chronic liver disease targeting immune responses, introduction)

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    Study English 發佈於 2021 年 01 月 14 日