Name: 癌症治療找到重大突破了？！ (Major breakthrough in cancer treatment)
Uploaded: 2025-04-30T21:01:10.000Z
Duration: 1 min 59 s

程度副詞

When Maureen Sideris was diagnosed with gastroesophageal cancer over two years ago, doctors told her she wouldn't just need chemo and radiation,

兩年多前，當 Maureen Sideris 被診斷出患有胃食管癌時，醫生告訴她不僅需要化療和放療，

but they would also have to remove part of her esophagus and stomach.

還必須切除她的部分食道和胃。

I wouldn't be able to eat or talk, my two favorite things in life, are you kidding me?

我不能吃東西，也不能說話，這是我生命中最喜歡的兩件事，你在開玩笑嗎？

But then she found a promising clinical trial for patients like her with tumors that have a genetic mutation called mismatch repair deficiency.

但後來，她發現了一項很有前景的臨床試驗，該試驗針對的是像她這樣患有名為錯配修復缺陷的基因突變腫瘤的患者。

All our cells in the body, when they divide, they make mistakes.

我們體內的所有細胞在分裂時都會犯錯。

And mismatch repair corrects those mistakes, and these tumors to gain an advantage, the tumors have shut down mismatch repair.

錯配修復可以糾正這些錯誤，而這些腫瘤為了獲得優勢，關閉了錯配修復。

Any tumor can have the mutation, but they predominantly affect colorectal, gastric, pancreatic, and endometrial cancers.

任何腫瘤都可能有這種突變，但它們主要影響結腸直腸癌、胃癌、胰腺癌和子宮內膜癌。

The trial, co-led by Dr. Luis Diaz, had patients skip surgery and instead take an immunotherapy drug.

該試驗由路易斯·迪亞茲博士共同領導，患者無需手術，而是服用免疫療法藥物。

So this immunotherapy is is not just revving the immune system up to fight the tumor, it's exposing the tumor and if the reality is the tumor looks foreign, it will wipe it out of the body.

這種免疫療法不僅僅是讓免疫系統振奮起來對抗腫瘤，它還暴露了腫瘤，如果現實情況是腫瘤看起來是外來的，它就會把它從體內消滅掉。

Today that study finding, the experimental approach is 80% effective in people with the mutation.

如今，這項研究發現，實驗方法對突變患者的有效率達到了 80%。

This is Maureen, and you see here her active esophageal cancer when we first met her.

這是 Maureen，你可以看到我們第一次見到她時，她的食道癌正處於活動期。

That highlighted area right there. - Right there.

那個突出顯示的區域。 - 就在那裡。

And then after treatment, you can see that that area disappears. It's gone.

治療後，你可以看到該區域消失了。它不見了。

Any tumor that needs to go for surgery should be checked for mismatch repair, and in 80% of patients, we might be able to avoid surgery.

任何需要進行手術的腫瘤都應進行錯配修復檢查，80% 的患者可能可以避免手術。

Less than a year after her diagnosis, Maureen had no evidence of cancer.

在確診後不到一年的時間裡，莫琳沒有發現任何癌症跡象。