Name: 免疫系統：先天性防禦和適應性防禦先天性防禦和適應性防禦。 (The Immune System: Innate Defenses and Adaptive Defenses)
Uploaded: 2021-01-14T08:37:13.000Z
Duration: 13 min 44 s
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It's Professor Dave, I wanna tell you about the immune system.

Every single day, in everything we do, we are coming into contact with countless pathogens.

關係子句

These are bacteria and viruses that could potentially do great harm to us macroscopic

beings by interfering with our cellular activity.

How do we withstand these microscopic threats?

Fortunately, every human possesses an immune system that is well-equipped to protect us,

The immune system can be split up into two parts.

There is the innate defense system, and the adaptive defense system.

The innate is the part that is always ready to go.

It begins with external membranes, like the skin and a variety of mucous membranes.

This separates what's inside from what's outside, but of course, there are lots of

ways for pathogens to get past this barrier.

That's why we have internal defenses like antimicrobial proteins, phagocytes, and other

entities that are able to inhibit the spread of the invaders throughout the body.

Then there is the adaptive defense system.

This is much more sophisticated, as it involves a response that is specific to the type of

invader, made possible by things called antibodies, which we will get to a little later.

These two systems communicate and work together to keep us healthy and safe every day.

Let's start by taking a closer look at the innate defenses, starting with the surface

These are very effective at blocking pathogens from entering the body.

Epithelial cells on the surface are highly keratinized, so as long as it is unbroken,

That's why we can easily get infections when we have cuts on the skin, because pathogens

Wherever we have natural openings and body cavities, these are lined with mucosae that

They tend to be acidic, which inhibits bacterial growth.

Many of them have lysozymes, which destroy bacteria.

If mucus lines a particular passageway, microorganisms tend to get stuck there.

We can even find defensins, which are antimicrobial peptides.

But of course, no matter how effective these are, some pathogens will get through.

That's where the internal innate defenses come into play.

The hallmark of this system is the inflammatory response.

Before we go through that, let's mention phagocytes, which can perform phagocytosis.

This is when a cell engulfs some pathogen or other debris, and it sits inside in a vesicle.

This vesicle will merge with a lysosome, which has acid hydrolase enzymes that can digest

whatever is nearby, leaving it in tiny pieces.

These pieces then leave the cell by exocytosis, unable to do any harm.

The biggest and best phagocytes are macrophages, which are derived from white blood cells.

There are also natural killer cells which circulate in blood and lymph that can kill

cancer cells and virus-infected cells early on, simply by detecting certain abnormalities

in the cell, and inducing apoptosis in the cell, which is programmed cell death.

Phagocytes are also part of the inflammatory response.

This occurs when body tissues are injured in some way, by physical trauma, heat, or infection.

This begins with the release of inflammatory chemicals like histamine into the extracellular fluid.

In addition, macrophages as well as cells of certain boundary tissues have receptors

that enable them to recognize pathogens, sometimes with great specificity, and this kind of event

will trigger a release of cytokines, which are another type of inflammatory chemical.

What these chemicals do, is they cause local arterioles to dilate, and nearby capillaries

to leak slightly, otherwise known as vasodilation and vascular permeability.

The excess of blood in the area causes the redness and swelling that we can visibly see

Although this generates pain because of the pressure on nearby nerve endings, it is a

favorable strategy, because the rush of fluid sweeps any foreign material into lymphatic

vessels, so that it can be broken down in the lymph nodes, and the fluid also delivers

proteins that are important for clotting to aid in repair.

Once inflammation has initiated, phagocytes then rush the scene, first neutrophils, and

This begins when phagocytes enter the bloodstream from the red bone marrow, so they can get

Then in margination, they cling to capillary walls at the site of injury, recognizing molecular

In diapedesis, they squeeze out of the capillary.

Chemotaxis will then occur, where phagocytes migrate up the gradient of certain molecules

that act as a homing device for the site of injury, ready to eat up any intruders.

So that covers the basics regarding the innate defenses.

This is the part of the immune system that can learn about any foreign substance it comes

into contact with, which we call antigens, and develop the ability to protect the body

from that specific antigen any time in the future.

But how can your immune system have such an incredible memory?

To understand this, we have to learn about antibodies.

These are large Y-shaped proteins that are produced by lymphocytes, and they circulate

in the blood and lymph, looking for pathogens, which they are able to mark such that phagocytes

The word antigen is derived from the phrase “antibody generating”, so the word refers

to any foreign substance that will be recognized as being not of the self, and will thus provoke

These can be proteins, polysaccharides, lipids, any large molecule that doesn't belong,

as well as many pathogens, as these will bear foreign surface proteins that can also be

The part of the foreign substance that interacts with the immune system is called the antigenic

An antibody or lymphocyte will bind in a way that resembles enzyme-substrate interactions,

and different lymphocytes will recognize different determinants.

These include B lymphocytes or T lymphocytes, depending on what type of immunity they oversee,

and there are also antigen-presenting cells.

Lymphocytes of either variety originate inside red bone marrow, from hematopoietic stem cells.

They then become immunocompetent, meaning they gain the ability to recognize a particular

antigen, and once committed to a particular antigen, thousands of surface receptors are

produced that are devoted to that recognition.

On B cells these receptors are actually membrane-bound antibodies.

These lymphocytes must recognize certain proteins, but also learn self-tolerance, meaning they

Cells that fail to do this are forced to undergo apoptosis, and in fact only about two percent

of T cells will make it, but the ones that do will rapidly divide to make many copies