Name: TED】我們能用激光治療艾滋病嗎？| 姆通茲｜TED演講 (【TED】Could We Cure HIV with Lasers? | Patience Mthunzi | TED Talks)
Uploaded: 2021-01-14T05:50:24.000Z
Duration: 4 min 26 s

But for this pill to get to your head, where the pain is,

但要使這片藥到達你的頭， 也就是疼痛的地方，

it goes through your stomach, intestines and various other organs first.

它要經過你的胃，腸，和許多其他器官。

Swallowing pills is the most effective and painless way of delivering

口服藥片是最有效且無痛的給藥方式，

The downside, though, is that swallowing any medication leads to its dilution.

然而不利之處在於， 口服藥品會引起藥物的稀釋。

And this is a big problem, particularly in HIV patients.

這是個大問題，尤其對於HIV患者來說。

these drugs are good for lowering the virus in the blood,

這些藥物能夠降低血液中病毒的含量，

并提升CD4細胞(一種免疫細胞)的數量。

But they are also notorious for their adverse side effects,

但它們也擁有很嚴重的副作用，

but mostly bad, because they get diluted by the time they get to the blood,

其中最大的問題在於，它們在 到達血液的時候已經稀釋，

and worse, by the time they get to the sites

where it matters most: within the HIV viral reservoirs.

這是最重要的地方： 當HIV病毒潛伏在宿主體內時，

These areas in the body -- such as the lymph nodes,

它們存在於身體裡面，諸如淋巴結、

the nervous system, as well as the lungs --

and will not readily get delivered in the blood

of patients that are under consistent anti-HIV drugs therapy.

只要病人持續使用抗HIV的藥物。

However, upon discontinuation of therapy,

the virus can awake and infect new cells in the blood.

病毒就會甦醒並侵染血液中的新細胞。

Now, all this is a big problem in treating HIV with the current drug treatment,

如今，上述弊端已成為運用 目前藥物治療HIV的大問題。

which is a life-long treatment that must be swallowed by patients.

也就意味著病人需要終身服藥。

"Can we deliver anti-HIV directly within its reservoir sites,

“我們能否直接向 病毒的潛伏處注入抗HIV藥物，

As a laser scientist, the answer was just before my eyes:

作為一名雷射光科學家，答案是顯而易見的：

糖尿病傷口修復以及外科手術，

they can be used for anything imaginable,

那麼它們可以被運用於任何可以想到的領域，

As a matter of fact, we are currently using laser pulses

事實上，我們正在運用雷射光脈衝

在HIV感染的細胞上戳或鑽出極小的孔，

which open and close almost immediately in HIV-infected cells,

”這怎麼可能？“你可能會問。

Well, we shine a very powerful but super-tiny laser beam

是這樣，我們將一束能量極高且極其細的雷射光

照射在被HIV感染細胞的細胞膜上

while these cells are immersed in liquid containing the drug.

這些細胞被侵泡在含有藥物的液體里。

The laser pierces the cell, while the cell swallows the drug

the induced hole becomes immediately repaired.

Now, we are currently testing this technology in test tubes

現在，我們正在培養皿或者試管中，

but the goal is to get this technology in the human body,

目標在於將這項技術運用於人體，

“這怎麼可能？”你也許會問。

Well, the answer is: through a three-headed device.

是這樣的，通過一種三頭儀器。

Using the first head, which is our laser,

we will make an incision in the site of infection.

我們會用它對感染部位經行切割。

Using the second head, which is a camera,

Finally, using a third head, which is a drug-spreading sprinkler,

最後，第三個頭是一個噴藥頭，

we deliver the drugs directly at the site of infection,

我們將藥物直接注入到感染部位，

while the laser is again used to poke those cells open.

與此同時，激光將細胞刺穿一個孔。

Well, this might not seem like much right now.

目前這看起來還不是那麼成熟。

But one day, if successful, this technology can lead

但終有一天，如果我們能夠成功，這項技術將

to complete eradication of HIV in the body.

這是每一個HIV研究者的夢想﹣﹣

對於我們來說，就是雷射光治療法。