Name: 生物黑客。你能建立一個更好的自己嗎？| BBC創意 (Biohacking: Can you build a better you? | BBC Ideas)
Uploaded: 2022-09-15T17:51:34.000Z
Duration: 21 min 23 s

The idea of slowing down the ageing process and living healthier,

延緩衰老過程和活得更健康的想法。

情態副詞

more productive lives is hugely appealing.

更有成效的生活是非常有吸引力的。

It's led to a growing trend for people looking to take control

這導致了人們尋求控制的趨勢越來越大

of their own biology, optimising their bodies

他們自己的生物學，優化他們的身體

通過生物黑客技術，使人們的生活和思想得到改善。

And are there more natural ways of boosting your biology?

那麼是否有更自然的方法來提高你的生物學水準？

In this film, we're going to hear from both the biohackers

在這部影片中，我們將聽到生物黑客們的聲音

trying to push human health and wellbeing to its limits,

試圖將人類的健康和福祉推向極限。

and those taking more traditional scientific approaches.

和那些採取更傳統的科學方法的人。

戴夫-阿斯佩裡是一位美國企業家

and the self-described father of biohacking.

以及自稱是生物黑客之父的人。

I fully expect, and this is not a made-up number,

我完全期待，這不是一個捏造的數字。

unless something like a tree falling on me takes me out.

除非有像樹倒在我身上這樣的事情把我幹掉。

A lot of people ask, can we really hack the ageing process?

很多人問，我們真的能破解衰老過程嗎？

And we are now on the cusp, with literally about 50

而我們現在正處於風口浪尖上，實際上有大約50個

different innovations to control biology of ageing coming online

控制老化生物學的不同創新方法即將上線

And I have 100% certainty that within a few years,

而且我有100%的把握，在幾年之內。

our new innovations that come in happen faster than our ageing.

我們的新創新比我們的老齡化發生得更快。

It's certainly true that the scientific understanding of ageing

當然，對老齡化的科學理解是真實的

has progressed rapidly in recent decades, but why is that?

近幾十年來進展迅速，但這是為什麼呢？

I think one of the really big surprises that's come along

我認為出現的一個真正的大驚喜是

老齡化的特點是它的可塑性很強。

And I think what's come as a huge surprise is that sometimes

而我認為讓人大吃一驚的是，有時

the same thing will extend the healthy lifespan of a fly

同樣的事情可以延長蒼蠅的健康壽命

And what that's telling us, of course, is that some

of the underlying mechanisms of ageing that we're interfering with

我們正在干擾的老化的基本機制的一部分

So I think that's why ageing has opened up, really, to research

是以，我認為這就是為什麼老齡化已經打開了，真的，研究

in recent years - the discovery that we can use these short-lived things

近年來，我們發現，我們可以利用這些短命的東西

where we can get the answers more quickly to understand

在那裡我們可以更快得到答案，以瞭解

what's going on in the creatures that we really care about,

在我們真正關心的生物中發生了什麼。

As the science of ageing and longevity becomes more advanced,

隨著老齡化和長壽的科學變得更加先進。

we're learning how to not just slow down gradually

我們正在學習如何不只是逐漸放慢速度

the effects of ageing, but truly reverse many aspects of ageing.

衰老的影響，但真正扭轉衰老的許多方面。

We believe the cells in our bodies have youthful information

我們相信我們身體裡的細胞有年輕的資訊

when we're born and over time they lose that information.

當我們出生時，隨著時間的推移，他們會失去這些資訊。

We've discovered that there's information in the cell

我們已經發現，細胞中存在著資訊

to reset the system in the way that you could reboot a computer

重置系統，就像你重啟計算機一樣。

For example, we've recently reprogrammed the eye of an old mouse

例如，我們最近對一隻老老鼠的眼睛進行了重新編程

to be young again and those old mice get their vision back.

重新變得年輕，而那些老老鼠也恢復了他們的視力。

And that's just the beginning, I believe, of being able to turn

我相信，這只是一個開始，能夠把

the clock back, literally, to make younger tissues in the body.

時間倒流，從字面上看，是為了使身體的組織更年輕。

There are several companies within the growing longevity industry

在不斷增長的長壽產業中，有幾家公司

who are working on developing regenerative therapies

One such company is Elevian, who are investigating how a protein

Elevian公司就是這樣一家公司，他們正在研究如何將一種蛋白

found in young blood might have surprising

在年輕的血液中發現，可能有令人驚訝的

Our co-founders were part of a team that really made some

我們的聯合創始人是一個團隊的一部分，他們真正做出了一些

important discoveries - that young blood can rejuvenate aged animals

重要的發現--年輕的血液可以使年老的動物恢復活力

and vice versa - aged blood can accelerate ageing in young animals,

反之亦然--老化的血液可以加速年輕動物的老化。

and out of that work, they identified this little known factor

在這項工作中，他們發現了這個鮮為人知的因素

called GDF 11 that decreases with age, and what we and other labs

被稱為GDF 11的物質會隨著年齡的增長而減少，我們和其他實驗室的研究發現

have now found is that a very similar dose range of GDF 11

現在發現，在一個非常相似的劑量範圍內的GDF 11

and prevent dozens of age-related diseases.

並預防幾十種與年齡有關的疾病。

This research, which originally began on mice,

這項研究，最初在小鼠身上開始。

is still in its early pre-clinical stage.

Any drug development process which arises from it

has to be thorough, which can take years.

必須是徹底的，這可能需要幾年時間。

Elevian estimate that they are about a year away

Elevian估計，他們大約還有一年的時間。

For those impatient to slow down their ageing process

對於那些迫不及待想延緩衰老的人來說

and not keen to take part in experimental trials,

there are steps that people can take in their daily lives.

人們可以在日常生活中採取一些措施。

In many ways, our fight during ageing is in our own hands already.

在許多方面，我們在老齡化過程中的鬥爭已經掌握在我們自己手中。

It's really clear that if you can, you should take as much exercise

真的很清楚，如果你可以，你應該儘可能多地鍛鍊身體。

and also eat a healthy diet and not eat too much.

而且還要健康飲食，不要吃得太多。

Dr David Sinclair believes certain stresses on the body

大衛-辛克萊博士認為身體上的某些壓力

If you do the things that trick the body into thinking

如果你做那些欺騙身體的事情，讓他們認為

times could be tough - short bouts of skipping meals,

時代可能很艱難--短時的不吃飯。

so hunger, fasting, but also losing your breath.

所以飢餓、禁食，但也會失去呼吸。

So running on a treadmill, doing a lot of heavy weight lifting.

所以在跑步機上跑步，做了很多重體力活。

We also think that these are another way to promote the body's defences.

我們還認為，這些是促進身體防禦的另一種方式。

And the combination of all of those things actually is known

而所有這些東西的組合實際上是已知的

to extend lifespan by keeping people healthier for longer.

通過使人們更健康地生活，延長壽命。

Some biohackers are determined to go further

and are willing to trial experimental therapies

I decided that I wanted to try every extreme intervention I could -

我決定，我想嘗試每一種可能的極端干預措施------。

so that I could write about it and so that I could benefit from it.

這樣我就可以寫下它，這樣我就可以從中受益。

I've had my bone marrow taken out, spun down to get stem cells

我的骨髓已被取出，旋轉後得到了幹細胞。

and reintroduced the stem cells throughout my body.

並將幹細胞重新引入我的整個身體。

There's 150 supplements a day that are part of my regime

每天有150種補充劑，是我制度的一部分

我是一隻小白鼠，看看哪些是有效的。

There are different degrees of how far people want to go