So today we are going to explain exactly what happens to your brain and body.

是以，今天我們要解釋一下到底在你的大腦和身體上發生了什麼。

When you try to quit alcohol after six hours of quitting, you will start to feel unusual things.

當你嘗試戒酒的六個小時後，你會開始感覺到不尋常的事情。

But this will always correlate with how much alcohol you've been drinking prior to trying to quit Scientifically and academically we no longer use the term alcoholic.

但這總是與你在嘗試戒酒之前喝了多少酒有關 科學上和學術上，我們不再使用酒精中毒這個詞。

Let's take it out of the vocab Instead, what we now say is that people fall on the spectrum of alcohol use disorders.

讓我們把它從詞彙中拿出來 相反，我們現在說的是，人們屬於酒精使用障礙的範圍。

Also known as a U.

也被稱為U。

D.

D.

S.

S.

For example, you could have a mild alcohol use disorder or a severe one.

例如，你可能有輕微的酒精使用障礙或嚴重的酒精使用障礙。

A series of questions on life experience help academics and medical professionals decide where you fall.

一系列關於生活經歷的問題幫助學術界和醫學界人士決定你屬於哪一類。

For example, trying to cut back and being unable to maine for a mild alcohol use disorder continuing to drink, even though it continually causes negative emotions.

例如，試圖削減，無法緬因輕度酒精使用障礙繼續喝酒，即使不斷引起負面情緒。

Can infer a moderate alcohol use disorder.

可以推斷出有中度酒精使用障礙。

Whereas consistently drinking and driving constitutes a severe one.

而一貫的酒後駕駛則構成嚴重的。

There's a lot more detail to it and we'll put a link in the description below.

還有很多細節，我們會在下面的描述中放一個鏈接。

So you can actually take the survey.

所以你可以真正參加調查。

It could be eye opening.

這可能會讓人大開眼界。

I think I might have a mild one.

我想我可能有一個輕度的問題。

It can help you start to understand where you fall but most of the research that we are going to be talking about today has to do with people who have moderate To severe alcohol use disorders after 12-24 hours is when serious issues can happen.

它可以幫助你開始瞭解你的處境，但我們今天要討論的大多數研究都是與那些有中度至重度酒精使用障礙的人有關的，12-24小時後就會發生嚴重問題。

Extreme excitation in the brain from quitting alcohol can lead to delirium tremens, which results in seizures hallucinations that can last up to seven days or longer and potentially result in death.

戒酒後大腦的極度興奮會導致震顫性譫妄，導致癲癇發作的幻覺，可持續七天或更長時間，並有可能導致死亡。

If not recognized.

如果不承認。

The rate of mortality from delirium tremens is between 1 to 5%.

震顫性譫妄的死亡率在1%到5%之間。

This is why you or anyone with severe AU D.

這就是為什麼你或任何患有嚴重AU D的人。

Needs to talk to a medical professional before quitting because there are different drugs, medications or ways that you might have to wean yourself off the alcohol in order to not die.

在戒酒前需要與專業醫生交談，因為有不同的藥物、藥品或方法，你可能要把自己的酒斷掉，才能不死。

The reason this can happen is because alcohol changes the way your brain and nervous system work.

之所以會發生這種情況，是因為酒精改變了你的大腦和神經系統的工作方式。

Alcohol is absorbed in the stomach and small intestine where it enters the bloodstream and makes its way to your brain here.

酒精在胃和小腸中被吸收，在那裡它進入血液並在這裡進入你的大腦。

It suppresses excitatory neurons affected by the neurotransmitter glutamate and enhances inhibitory neurons affected by the neurotransmitter gaba.

它抑制受神經遞質穀氨酸影響的興奮性神經元，增強受神經遞質伽巴影響的抑制性神經元。

If I ever become a drag queen, I want my name to be glutamate gaba neurologically you get in theory less excitation and more inhibition, which is why you have likely heard that alcohol is a depressant, but the reason you may feel euphoric is because the increased Gaba inhibition means information in the brain becomes slower and only the largest signals make it through this clarifies your thoughts, It can make you feel amazed at your own simple ideas which can lead to serotonin release.

如果我成為變裝皇后，我希望我的名字是穀氨酸加巴，從理論上講，你會得到更少的興奮和更多的抑制，這就是為什麼你可能聽說酒精是一種抑制劑，但你可能感到興奮的原因是，加巴抑制的增加意味著大腦中的資訊變得緩慢，只有最大的信號才能通過，這澄清了你的想法，它可以讓你對自己的簡單想法感到驚訝，這可以導致血清素的釋放。

But when you stop drinking the inhibition from the alcohol stops and this can lead To the excitatory overload.

但當你停止飲酒時，酒精的抑制作用就會停止，這可能導致興奮性過載。

This is why you might get shakes, seizures, hallucinations and the tragic delirium tremens that can occur in some people with alcohol use disorders after 24-48 hours of no alcohol, most people start to feel agitated.

這就是為什麼你可能會出現顫抖、癲癇發作、幻覺和悲慘的震顫性譫妄，在一些有酒精使用障礙的人中，在24-48小時不喝酒後，大多數人開始感到煩躁。

That surge of serotonin you get from the clear thoughts and the uninhibited experiences of alcohol are no longer happening in your brain.

你從清晰的思想和無拘無束的酒精體驗中獲得的那種血清素激增不再在你的大腦中發生。

You start to feel worse because there's actually lower baseline levels of serotonin in your brain when you quit.

你開始感覺更糟，因為當你戒菸時，你的大腦中血清素的基線水準實際上較低。

And some people at this point start to drink again because they want to feel better.

而有些人在這個時候又開始喝酒，因為他們想讓自己感覺更好。

But it's important to remember that drinking will never make you feel better in the long run.

但重要的是要記住，從長遠來看，喝酒絕不會讓你感覺更好。

That's sort of the classic tale with this substance that we all seem to be consuming 2 to 3 days after quitting and your brain has increased cortical trope in releasing hormone which can cause an increase in cortisol release which leads to a lack of appetite, increased anxiety and focused but stressful energy.

這算是這種物質的經典故事，我們似乎都在戒菸後的2到3天內消耗了這種物質，你的大腦在釋放激素方面的皮質特質增加，這會導致皮質醇釋放增加，從而導致食慾不振，焦慮增加，精力集中但壓力很大。

All this bad stuff is happening again because when you are drinking you're actually physiologically changing the shape of your brain and therefore when you stop it has to cope with a lot of those changes.

所有這些不好的事情又發生了，因為當你喝酒的時候，你實際上在生理上改變了你的大腦的形狀，是以當你停下來的時候，它必須應對很多這些變化。

And to be honest I don't need any more focused and stressful energy in my life animal studies as well as post mortem brain scans of people with a U.

而且說實話，我不需要在我的生活中再有任何集中和緊張的能量，動物研究以及U型人的死後大腦掃描。

D.

D.

Show that exposure to alcohol alters the expression of genes involved in diverse cellular functions.

表明接觸酒精會改變參與不同細胞功能的基因的表達。

There are literal changes in M.

M中存在著字面上的變化。

RNA coding in the prefrontal cortex that and they see the ventral take mental area of the brain.

前額葉皮層中的RNA編碼，他們看到大腦的腹側採取心理區域。

And another study found that 163 genes in the superior frontal cortex of your brain were altered in people with A.

而另一項研究發現，在患有A的人中，大腦上額皮層的163個基因發生了改變。

D.

D.

So yes drinking alcohol literally changes the structure of your brain.

是以，是的，飲酒會從字面上改變你的大腦結構。

Three days after quitting in the straddle dopamine transporter binding portion of the brain that was decreased while drinking will stay low and in some cases go even lower than before.

戒菸三天後，在喝酒時減少的大腦多巴胺轉運器結合部分將保持低水平，在某些情況下甚至比以前更低。

This will make it harder for you to feel good in any way while sober.

這將使你在清醒時更難有任何好的感覺。

2 to 3 days after quitting dopamine is a very biochemically complicated molecule and a lot of pop science will just let you know I feel like a hormone there's a lot more to it than that.

戒菸後2到3天，多巴胺是一個非常複雜的生化分子，很多流行的科學只會讓你知道我感覺像一種激素，還有很多東西是不一樣的。

But in this specific context it may be worth thinking of it like this but thankfully on day four is when things start to get better day four of quitting and the lower dopamine transporters start to change back to baseline.

但在這個特定的背景下，可能值得這樣想，但值得慶幸的是，在第四天是事情開始變得更好的時候，戒菸的第四天，較低的多巴胺轉運體開始改變，回到基線。

And the biggest change happens after four days of being sober.

而最大的變化發生在清醒的四天後。

This is when you can picture that your brain is starting to alter in a way that is now positively benefiting your health.

這時你可以想象，你的大腦開始以一種現在對你的健康有積極好處的方式改變。

Three weeks after quitting and your gut is now starting to heal because a U.

戒菸三週後，你的腸胃現在開始癒合，因為一個U。

D.

D.

Leads to leaky gut issues essentially it messes with the bacteria in your G.

導致腸漏問題，基本上它擾亂了你G中的細菌。

I.

I.

Tract which can lead to depressive symptoms continuing in the three weeks after quitting.

道，這可能導致抑鬱症狀在戒菸後的三週內持續。

There's growing research between the link between your gut microbiome and the specific enzyme trip to fan di hydrogen ease trip to fans and amino acid is not just a random thing you eat in turkey.

在你的腸道微生物組和特定的酶絆扇二氫緩和絆扇和氨基酸之間的聯繫的研究越來越多，這並不是你在火雞中隨意吃的東西。

It's synthesized by Kairouan in and this Biological process is messed up when you drink because of the way the alcohol is affecting the gut microbiome.

它是由犬尿氨酸（kynurenine）合成的，當你喝酒時，這個生物過程會被打亂，因為酒精影響了腸道微生物組的方式。

And it's this specific reason why you might be feeling depressed after quitting alcohol.

而這正是你在戒酒後可能感到抑鬱的具體原因。

It's essentially that you just messed with your microbiome and now you're feeling the effects as it heals.

本質上是你剛剛擾亂了你的微生物組，現在你正在感受它癒合的影響。

So in the first three weeks this gut issue is still happening.

所以在前三週，這個腸道問題仍在發生。

You're feeling more depressed but it's around 4-8 weeks after quitting.

你感覺更加抑鬱，但這是在戒菸後4-8周左右。

That your gut starts to level out.

你的腸胃開始變得平和。

According to two recent studies.

根據最近的兩項研究。

Again this is all about knowledge being power.

這又是關於知識就是力量。

So you can have sympathy for your bodies, may be depressed, response to quitting alcohol.

是以，你可以同情你的身體，可能是抑鬱的，對戒酒的反應。

Four weeks after quitting and you will be getting way better sleep.

戒菸四周後，你的睡眠品質會有很大提高。

27 studies found you fall asleep faster with alcohol.

27項研究發現，飲酒後會更快入睡。

That sounds good but it screws with your ability to have high sleep quality.

這聽起來不錯，但它破壞了你擁有高睡眠品質的能力。

Once asleep drinking before bed increases alpha wave patterns in the brain.

一旦入睡，睡前喝酒會增加大腦中的α波模式。

So when trying to sleep after drinking your brain's kind of acting similarly to when you are awake but only resting on the couch.

是以，當試圖在飲酒後睡覺時，你的大腦的行為有點類似於你醒著但只是在沙發上休息的時候。

Sleep disturbances are high in people with a U.

睡眠障礙在患有U.S.A.的人中很高。

D.

D.

With rapid eye movement and N.

隨著快速眼動和N。

Three slow wave sleep being altered by the alcohol.

三個慢波睡眠被酒精改變了。

And it can take up to four weeks for the issues to start to slow down sleep related regions of your brain vastly overlap with parts of the brain where people with a U.

而這些問題可能需要四個星期的時間才能開始減緩，你大腦中與睡眠有關的區域與患有U.S.A.的人的大腦部分有很大的重疊。

D.

D.

Have decreased gray matter.

有灰色物質減少。

It can take up to three months for gray matter to change in the brain.

大腦中的灰質變化可能需要三個月的時間。

So again after you quit drinking it may take three months to have the best quality sleep you could get after five weeks.

是以，再次戒酒後，可能需要三個月的時間，才能在五週後獲得最佳的睡眠品質。

You will see improvements in your skin looking great.

你會看到你的皮膚看起來很好的改善。

But because drinking causes dehydration as alcohol binds to the protein in your body that re absorbs water back into the body meaning you pee out excess water while you're drinking.

但是因為喝酒會導致脫水，因為酒精與你體內的蛋白質結合，重新將水吸收回體內，這意味著你在喝酒時尿出多餘的水。

This is the water that your body would have otherwise kept inside you to stay hydrated.

這是你的身體本來會保存在你體內以保持水分的水。

To studies I found I will be honest they weren't the best studies said that this can also lead to decreased collagen levels in your skin.

對於我發現的研究，我會誠實地說他們不是最好的研究，說這也會導致你的皮膚中膠原蛋白水準下降。

There's much more clear studies about how severe A.

關於嚴重的A.有更明確的研究。

U.

U.

D.

D.

Can lead to psoriasis, broken blood vessels in your skin and these will be starting to heal around five weeks after six weeks of quitting.

可能導致銀屑病，皮膚上的血管破裂，這些在戒菸六週後的五週左右就會開始癒合。

Three studies found that people who quit alcohol had higher thinking skills, problem solving skills, memory and attention than those who did not quit drinking.

三項研究發現，戒酒的人比沒有戒酒的人有更高的思維能力、解決問題的能力、記憶和注意力。

Also, there's these big meta analysis that you could read about how stopping drinking will decrease your ability to get cancer ability to get a stroke, ability to literally die earlier.

還有，你可以讀到這些大型的元分析，關於停止飲酒將減少你得癌症的能力，得中風的能力，實際上是更早地死亡。

So I have been making these videos with the most up to date scientific research about the neurology, neurophysiology and biological pathways involved with quitting different things like marijuana or porn.

是以，我一直在用最新的科學研究製作這些視頻，內容涉及戒除大麻或色情等不同事物的神經學、神經生理學和生物途徑。

But the alcohol research that I've been doing, I've been doing it honestly, the whole time has been the most intense and scary research and it's interesting because it's sort of the most common and socially accepted drug.

但我一直在做的酒精研究，說實話，我一直在做的是最緊張、最可怕的研究，這很有趣，因為它算是最常見、最被社會接受的藥物。

It's kind of pitched to us that like you get home from a long day at work and you have a little glass of wine and relax, but it's a slippery slope to a very dangerous future for yourself.

這對我們來說是一種坑，就像你從漫長的一天工作中回到家，你喝了一小杯酒，放鬆了一下，但這是一個滑坡，對你自己的未來非常危險。

People with severe au de need medical professionals to get off it.

患有嚴重au de的人需要專業醫療人員的幫助才能擺脫它。

Sometimes you need benzos to get off of it.

有時你需要苯丙胺類藥物來擺脫它。

You need antipsychotic drugs to do it safely, which is just like so scary.

你需要抗精神病藥物才能安全地做到這一點，這簡直是太可怕了。

You're relying on those drugs to get off of alcohol.

你依靠這些藥物來擺脫酒精的影響。

I didn't know about a lot of these things prior to this research, I'm not going to stop drinking, but what it has done for me is allowed me when I'm sitting down to have a brew with the boys or more realistically like having a martini and like dancing in a gay bar.

在這項研究之前，我不知道很多這些事情，我不會停止喝酒，但它對我的作用是允許我在坐下來和男孩們一起喝酒時，或者更現實的是像喝馬提尼酒一樣，在同志酒吧裡跳舞。

I'm just a little bit more aware of the impact that that drug is having on me.

我只是更清楚地意識到那種藥物對我的影響。

It's a serious drug.

這是一種嚴重的藥物。

Whereas before I think I thought of it more as like a kind of weird tasting liquid.

而以前我認為我更多地把它看作是一種味道古怪的液體。

It's also important to know that you're at a higher risk of having a U.

同樣重要的是，要知道你有U的風險更高。

D.

D.

If someone in your family has had it if you had a trauma growing up.

如果你的家人中有人得過這種病，如果你在成長過程中有過創傷。

And also if you started drinking Before the age of 15, so go forth with this knowledge and as your gay uncle, I am telling you okay hon drink responsibly.

還有，如果你在15歲之前就開始喝酒，那麼就帶著這些知識去吧，作為你的同志叔叔，我告訴你，好吧，負責任地喝酒。

Thank you for watching and subscribe for more science videos also produce.

謝謝你的觀看和訂閱更多的科學視頻也產生。