Name: 【TED-Ed】一窺阿茲海默症的秘密 What is Alzheimer's disease? - Ivan Seah Yu Jun
Uploaded: 2014-04-17T18:05:08.000Z
Duration: 3 min 50 s

affecting over 40 million people worldwide,

and yet finding a cure is something that still

Dr. Alois Alzheimer, a German psychiatrist,

愛羅斯．阿茲海默 是一位德國的精神科醫師

最早在 1901 年首次提出這個症狀

when he noticed that a particular hospital patient

her symptoms were caused by irregularities

in the fatty membrane surrounding nerve cells

immune reactions that cause the destruction

In Alzheimer's disease, neurofibrillary tangles

The brain's nerve cells contain a network of tubes

大腦的神經元包含了微管的網絡

that act like a highway for food molecules

供食物分子和其它東西用的公路

Usually, the tau protein ensures that these tubes

the protein collapses into twisted strands or tangles,

蛋白質崩壞成扭曲的束狀或結塊

obstructing nutrients from reaching the nerve cell

The destructive pairing of plaques and tangles

starts in a region called the hippocampus,

which is responsible for forming memories.

is usually the first symptom of Alzheimer's.

the proteins destroy the ability to process logical thoughts.

蛋白質破壞處理邏輯思考的能力

Next, they shift to the region that controls emotions,

接下來，它們會轉向情緒控制區

最後，主宰心跳和呼吸的控制中心

heart rate and breathing are overpowered as well

The immensely destructive nature of this disease

has inspired many researchers to look for a cure

but currently they're focused on slowing its progression.

helps reduce the break down of acetylcholine,

an important chemical messenger in the brain

乙醯膽鹼是大腦中重要的傳導物質

which is decreased in Alzheimer's patients

這種物質在阿茲海默症的病患中減少

due to the death of the nerve cells that make it.

that trains the body's immune system to attack

beta-amyloid plaques before they can form clumps.

在 β-類澱粉蛋白斑結塊前攻擊它

But we still need to find an actual cure.

但是我們還是需要找一個真正的解方

the exact mechanisms at work behind this threat

在研究中找到這個威脅背後的準確機制

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【TED-Ed】一窺阿茲海默症的秘密　What is Alzheimer's disease? - Ivan Seah Yu Jun

brain

structure

immune

disease