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  • In December 2019 the Chinese authorities

  • notified the world that a virus was spreading through their communities.

  • In the following months, it spread to other countries, with cases doubling within days.

  • This virus is the Severe Acute Respiratory Syndrome-Related Coronavirus 2

  • that causes the disease called Covid-19 and that everyone simply calls coronavirus.

  • What actually happens when it infects a human and what should we all do?

  • [Intro Music]

  • A virus is really just a hull around genetic material and a few proteins, arguably not even a living thing.

  • It can only make more of itself by entering a living cell.

  • Corona may spread via surfaces,

  • but it's still uncertain how long it can survive on them.

  • Its main way of spreading seems to be droplet infection when people cough, or if you touch someone who's ill and then your face,

  • say rubbing your eyes or nose.

  • The virus starts its journey here, and then hitches a ride as a stowaway deeper into the body

  • Its destinations are the intestines, the spleen or the lungs, where it can have the most dramatic effect.

  • Even just a few corona viruses can cause quite a dramatic situation.

  • The lungs are lined with billions of epithelial cells.

  • These are the border cells of your body, lining your organs and mucosa waiting to be infected.

  • Corona connects to a specific receptor on its victim's membranes to inject its genetic material.

  • The cell, ignorant of what's happening, executes the new instructions, which are pretty simple:

  • copy and reassemble.

  • It fills up with more and more copies of the original virus until it reaches a critical point and receives one final order,

  • self-destruct.

  • The cell sort of melts away, releasing new corona particles ready to attack more cells.

  • The number of infected cells grows exponentially

  • After about 10 days, millions of body cells are infected, and billions of viruses swarmed the lungs.

  • The virus has not caused too much damage yet, but is now going to release a real beast on you,

  • your own immune system.

  • The immune system, while there to protect you, can actually be pretty dangerous to yourself and needs tight regulation.

  • And as immune cells pour into the lungs to fight the virus, Corona infects some of them and creates confusion.

  • Cells have neither ears nor eyes.

  • They communicate mostly via tiny information proteins called cytokines.

  • Nearly every important immune reaction is controlled by them.

  • Corona causes infected immune cells to overreact and yell bloody murder in a sense

  • it puts the immune system into a fighting frenzy and sends way more soldiers than it should, wasting its resources and causing damage.

  • Two kinds of cells in particular wreak havoc

  • First, neutrophiles, which are great at killing stuff, including our cells.

  • As they arrive in their thousands, they start pumping out enzymes that destroy as many friends as enemies.

  • The other important type of cells that go into a frenzy are killer T-cells, which usually order infected cells to commit controlled suicide.

  • Confused as they are, they start ordering healthy cells to kill themselves too.

  • The more and more immune cells arrive, the more damage they do, and the more healthy lung tissue they kill.

  • This might get so bad that it can cause permanent irreversible damage, that leads to lifelong disabilities.

  • In most cases, the immune system slowly regains control.

  • It kills the infected cells, intercepts the viruses trying to infect new ones and cleans up the battlefield.

  • Recovery begins.

  • The majority of people infected by Corona will get through it with relatively mild symptoms.

  • But many cases become severe or even critical.

  • We don't know the percentage because not all cases have been identified,

  • but it's safe to say that there is a lot more than with the flu. In more severe cases,

  • Millions of epithelial cells have died and with them, the lungs' protective lining is gone.

  • That means that the alveoli - tiny air sacs via which breathing occurs - can be infected by bacteria that aren't usually a big problem.

  • Patients get pneumonia.

  • Respiration becomes hard or even fails, and patients need ventilators to survive.

  • The immune system has fought at full capacity for weeks and made millions of antiviral weapons.

  • And as thousands of bacteria rapidly multiply, it is overwhelmed.

  • They enter the blood and overrun the body; if this happens, death is very likely.

  • The Corona virus is often compared to the flu, but actually, it's much more dangerous.

  • While the exact death rate is hard to pin down during an ongoing pandemic, we know for sure that it's much more contagious and spreads

  • faster than the flu.

  • There are two futures for a pandemic like Corona: fast and slow.

  • Which future we will see depends on how we all react to it in the early days of the outbreak.

  • A fast pandemic will be horrible and cost many lives; a slow pandemic will not be remembered by the history books.

  • The worst case scenario for a fast pandemic begins with a very rapid rate of

  • infection because there are no counter measures in place to slow it down.

  • Why is this so bad?

  • In a fast pandemic, many people get sick at the same time.

  • If the numbers get too large, health care systems become unable to handle it.

  • There aren't enough resources, like medical staff or equipment like ventilators, left to help everybody.

  • People will die untreated.

  • And as more health care workers get sick themselves, the capacity of health care systems falls even further.

  • If this becomes the case, then horrible decisions will have to be made about who gets to live and who doesn't.

  • The number of deaths rises significantly in such a scenario.

  • To avoid this, the world - that means all of us - needs to do what it can to turn this into a slow pandemic.

  • A pandemic is slowed down by the right responses.

  • Especially in the early phase, so that everyone who gets sick can get treatment and there's no crunch point with overwhelmed hospitals.

  • Since we don't have a vaccine for Corona, we have to socially engineer our

  • behaviour, to act like a social vaccine. This simply means two things:

  • 1. Not getting infected; and 2. Not infecting others.

  • Although it sounds trivial, the very best thing you can do is to wash your hands.

  • The soap is actually a powerful tool.

  • The corona virus is encased in what is basically a layer of fat; soap breaks that fat apart and leaves it unable to infect you.

  • It also makes your hands slippery, and with the mechanical motions of washing, viruses are ripped away.

  • To do it properly, wash your hands as if you've just cut up some jalapeños and want to put in your contact lenses next.

  • The next thing is social distancing, which is not a nice experience,

  • but a nice thing to do. This means: no hugging, no handshakes.

  • If you can stay at home, stay at home to protect those who need to be out for society to function: from doctors to

  • cashiers, or police officers;. You depend on all of them; they all depend on you to not get sick.

  • On a larger level, there are quarantines, which can mean different things, from travel restrictions or actual orders to stay at home.

  • Quarantines are not great to experience and certainly not popular.

  • But they buy us - and specially the researchers working on medication and vaccinations - crucial time

  • So if you are put under quarantine, you should understand why, and respect it.

  • None of this is fun. But looking at the big picture, it is a really small price to pay.

  • The question of how pandemics end,depends on how they start; if they start fast with a steep slope, they end badly.

  • If they start slow, with a not-so-steep slope, they end okay-ish. And, in this day and age,

  • it really is in all of our hands.

  • Literally, and

  • figuratively.

  • A huge thanks to the experts who helped us on short notice with this video,

  • specially Our World In Data, the online publication for research and data on the world's largest problems and how to make progress solving them.

  • Check out their site. It also includes a constantly updated page on the Corona pandemic

In December 2019 the Chinese authorities

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