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  • Alcohol, one of the most commonly used and abused drugs in the world

    酒精,世上最常使用及濫用的藥物之一

  • comes in a variety of forms and does one thing quickly and well.

    它存在的形式多變,而且有個又快又好的效果

  • It changes the way you feel

    就是改變你感覺的方式

  • But to what do we owe these feelings of release and freedom?

    但我們又怎麼會有放鬆和解脫的感覺呢?

  • How could the ingestion of one simple substance

    只是吃了一種簡單的物質

  • so drastically change not only your actions

    怎麼就會讓你的行為

  • but thoughts and perception.

    思考還有感知改變這麼大!

  • As alcohol enters the body and makes its way to your brain,

    當酒精進入身體,到達腦部時

  • it begins to interact with your neurons or brain cells.

    它會開始和神經元或腦細胞作用

  • In our previous video on marijuana which you can click here

    這裡有一部我們先前在討論大麻的影片,你可以點這裡進去看看

  • we explain the actions of neurons and their chemical messengers called neurotransmitters.

    我們解釋了神經元的作用,還有它們的化學訊息傳遞者,神經遞質

  • But there are two main types of neurotransmitters

    神經遞質主要有兩大類

  • that these neurons use to communicate, or send electrical signals.

    神經元藉由它們來溝通或傳送電子訊息

  • Excitatory neurons use glutamate, while inhibitory neurons use GABA.

    產生刺激效果的神經元使用谷氨酸鹽,而產生抑制效果的神經元使用 γ-氨基丁酸 (GABA)

  • The yin and yang if you will.

    你可以想成是陰和陽

  • Much like the zeroes and ones of a computer, these two messengers have contrasting roles.

    和電腦裡的0和1滿類似的,這兩種訊息傳遞者有截然不同的作用

  • Glutamate begins a wave of excitation while GABA not only inhibits this flow,

    谷氨酸鹽產生刺激訊號,而 γ-氨基丁酸 (GABA) 不但能抑制刺激訊號

  • but helps to organize and differentiate the results in your brain.

    還能協助組織、區分腦袋裡的結果

  • And just like a computer, these signals can be combined in enormous complexity to form actions and thoughts.

    就像電腦,這些訊息可以組合起來,形成龐大的複雜體,進而產生動作或想法

  • So how does alcohol affect these two signals? Turns out it suppresses glutamate transmission

    那酒精是如何干擾這兩種訊息的呢?原來,酒精抑制了谷氨酸鹽的傳遞

  • and enhances GABA transmission, so you get less excitation and more inhibition.

    還增強了 γ-氨基丁酸 (GABA) 的傳遞,所以刺激訊息變少了,抑制訊息變多了

  • And because glutamate sites become less effective, information flow becomes slow,

    因為接收谷氨酸鹽位置的效率變差,訊息傳遞就變慢

  • and only the largest signals can make it through.

    只有較強的訊息能通過

  • This means you feel less, percieve less, notice less, and remember less.

    這表示你的知覺、意識、警覺和記憶都會變弱

  • In conjunction, the increased GABA hushes the excessive background noise of activity

    在神經元相接處,增多的 γ-氨基丁酸 (GABA) 會遮蔽過多的背景雜訊

  • fine tuning and clarifying your thoughts, but to an excessive degree.

    好好調教思緒、使其清晰,只是做得太過頭了

  • This is why you may have heard that alcohol is a depressant.

    這就是為什麼你可能聽過有人說,酒精是一種鎮靜劑

  • But inhibition of your neurons is not the same as social inhibition.

    神經元抑制和社會抑制是不同的

  • Instead, it simply cleans up and removes extraneous activity by removing less significant excitation.

    神經元抑制藉由消除次要刺激,來清除、取消外在活動

  • Without normal GABA transmission, the excessive excitatory action

    若沒有正常的 γ-氨基丁酸 (GABA) 傳遞,過多的刺激反應

  • would resemble a epileptic seizure

    就會像癲癇發作一樣

  • There'd be no clarity of thought.

    也就不會有清楚的意識

  • While drunk, your GABA channels are wide opened.

    酒醉時,γ-氨基丁酸 (GABA) 的通道大開

  • Combined with the lack of glutamate, you begin to think very little but with great clarity.

    再加上沒有谷氨酸鹽,你開始不太能思考,但意識清楚

  • It's what causes the momentums attitude of a drunk, often repeating the same idea

    這就是為什麼酒醉時會像鬼打牆一樣,一直重複同樣的想法

  • or proclamation over and over.

    或者一直唸肖話,一直唸、一直唸

  • Thinking clearly about almost nothing.

    沒有一件事情能好好思考

  • Hmm

  • Got a burning question you want answered?

    有迫切想得到解答的問題嗎?

  • Ask it in the comments or on Facebook and Twitter.

    在留言處提問吧,臉書或推特上也行

  • And subscribe for more weekly science videos.

    想看更多每周科學影片,歡迎訂閱

  • Subtitles written by the YouTube community.

    本字幕由YouTube社群編輯 (VoiceTube中譯)

Alcohol, one of the most commonly used and abused drugs in the world

酒精,世上最常使用及濫用的藥物之一

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