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由 AI 自動生成
  • The idea of slowing down the ageing process and living healthier,

    延緩衰老過程和活得更健康的想法。

  • more productive lives is hugely appealing.

    更有成效的生活是非常有吸引力的。

  • It's led to a growing trend for people looking to take control

    這導致了人們尋求控制的趨勢越來越大

  • of their own biology, optimising their bodies

    他們自己的生物學,優化他們的身體

  • and minds through biohacking.

    通過生物黑客技術,使人們的生活和思想得到改善。

  • But how safe and ethical is it?

    但它的安全性和道德性如何?

  • And are there more natural ways of boosting your biology?

    那麼是否有更自然的方法來提高你的生物學水準?

  • In this film, we're going to hear from both the biohackers

    在這部影片中,我們將聽到生物黑客們的聲音

  • trying to push human health and wellbeing to its limits,

    試圖將人類的健康和福祉推向極限。

  • and those taking more traditional scientific approaches.

    和那些採取更傳統的科學方法的人。

  • Dave Asprey is an American entrepreneur

    戴夫-阿斯佩裡是一位美國企業家

  • and the self-described father of biohacking.

    以及自稱是生物黑客之父的人。

  • I fully expect, and this is not a made-up number,

    我完全期待,這不是一個捏造的數字。

  • to live to at least 180 years old

    至少活到180歲

  • unless something like a tree falling on me takes me out.

    除非有像樹倒在我身上這樣的事情把我幹掉。

  • A lot of people ask, can we really hack the ageing process?

    很多人問,我們真的能破解衰老過程嗎?

  • And we are now on the cusp, with literally about 50

    而我們現在正處於風口浪尖上,實際上有大約50個

  • different innovations to control biology of ageing coming online

    控制老化生物學的不同創新方法即將上線

  • all at the same time.

    都在同一時間。

  • And I have 100% certainty that within a few years,

    而且我有100%的把握,在幾年之內。

  • our new innovations that come in happen faster than our ageing.

    我們的新創新比我們的老齡化發生得更快。

  • It's certainly true that the scientific understanding of ageing

    當然,對老齡化的科學理解是真實的

  • has progressed rapidly in recent decades, but why is that?

    近幾十年來進展迅速,但這是為什麼呢?

  • I think one of the really big surprises that's come along

    我認為出現的一個真正的大驚喜是

  • about ageing is how malleable it is.

    老齡化的特點是它的可塑性很強。

  • There are... Especially in animals.

    有的...特別是在動物身上。

  • And I think what's come as a huge surprise is that sometimes

    而我認為讓人大吃一驚的是,有時

  • the same thing will extend the healthy lifespan of a fly

    同樣的事情可以延長蒼蠅的健康壽命

  • but also of a mouse.

    但也是一隻老鼠的。

  • And what that's telling us, of course, is that some

    當然,這告訴我們的是,一些

  • of the underlying mechanisms of ageing that we're interfering with

    我們正在干擾的老化的基本機制的一部分

  • are in common between these animals.

    是這些動物之間的共同點。

  • So I think that's why ageing has opened up, really, to research

    是以,我認為這就是為什麼老齡化已經打開了,真的,研究

  • in recent years - the discovery that we can use these short-lived things

    近年來,我們發現,我們可以利用這些短命的東西

  • where we can get the answers more quickly to understand

    在那裡我們可以更快得到答案,以瞭解

  • what's going on in the creatures that we really care about,

    在我們真正關心的生物中發生了什麼。

  • particularly ourselves.

    特別是我們自己。

  • As the science of ageing and longevity becomes more advanced,

    隨著老齡化和長壽的科學變得更加先進。

  • we're learning how to not just slow down gradually

    我們正在學習如何不只是逐漸放慢速度

  • the effects of ageing, but truly reverse many aspects of ageing.

    衰老的影響,但真正扭轉衰老的許多方面。

  • We believe the cells in our bodies have youthful information

    我們相信我們身體裡的細胞有年輕的資訊

  • when we're born and over time they lose that information.

    當我們出生時,隨著時間的推移,他們會失去這些資訊。

  • We've discovered that there's information in the cell

    我們已經發現,細胞中存在著資訊

  • to reset the system in the way that you could reboot a computer

    重置系統,就像你重啟計算機一樣。

  • with fresh software.

    用新的軟件。

  • For example, we've recently reprogrammed the eye of an old mouse

    例如,我們最近對一隻老老鼠的眼睛進行了重新編程

  • to be young again and those old mice get their vision back.

    重新變得年輕,而那些老老鼠也恢復了他們的視力。

  • And that's just the beginning, I believe, of being able to turn

    我相信,這只是一個開始,能夠把

  • the clock back, literally, to make younger tissues in the body.

    時間倒流,從字面上看,是為了使身體的組織更年輕。

  • There are several companies within the growing longevity industry

    在不斷增長的長壽產業中,有幾家公司

  • who are working on developing regenerative therapies

    正致力於開發再生療法的人

  • to combat the diseases of ageing.

    以對抗老齡化的疾病。

  • One such company is Elevian, who are investigating how a protein

    Elevian公司就是這樣一家公司,他們正在研究如何將一種蛋白

  • found in young blood might have surprising

    在年輕的血液中發現,可能有令人驚訝的

  • regenerative capabilities.

    再生能力。

  • Our co-founders were part of a team that really made some

    我們的聯合創始人是一個團隊的一部分,他們真正做出了一些

  • important discoveries - that young blood can rejuvenate aged animals

    重要的發現--年輕的血液可以使年老的動物恢復活力

  • and vice versa - aged blood can accelerate ageing in young animals,

    反之亦然--老化的血液可以加速年輕動物的老化。

  • and out of that work, they identified this little known factor

    在這項工作中,他們發現了這個鮮為人知的因素

  • called GDF 11 that decreases with age, and what we and other labs

    被稱為GDF 11的物質會隨著年齡的增長而減少,我們和其他實驗室的研究發現

  • have now found is that a very similar dose range of GDF 11

    現在發現,在一個非常相似的劑量範圍內的GDF 11

  • can be used to treat

    可用於治療

  • and prevent dozens of age-related diseases.

    並預防幾十種與年齡有關的疾病。

  • This research, which originally began on mice,

    這項研究,最初在小鼠身上開始。

  • is still in its early pre-clinical stage.

    目前仍處於早期臨床前階段。

  • Any drug development process which arises from it

    由此產生的任何藥物開發過程

  • has to be thorough, which can take years.

    必須是徹底的,這可能需要幾年時間。

  • Elevian estimate that they are about a year away

    Elevian估計,他們大約還有一年的時間。

  • from beginning human clinical trials.

    從開始進行人體臨床試驗。

  • For those impatient to slow down their ageing process

    對於那些迫不及待想延緩衰老的人來說

  • and not keen to take part in experimental trials,

    並不熱衷於參加實驗性試驗。

  • there are steps that people can take in their daily lives.

    人們可以在日常生活中採取一些措施。

  • In many ways, our fight during ageing is in our own hands already.

    在許多方面,我們在老齡化過程中的鬥爭已經掌握在我們自己手中。

  • It's really clear that if you can, you should take as much exercise

    真的很清楚,如果你可以,你應該儘可能多地鍛鍊身體。

  • as is healthy,

    因為是健康的。

  • and also eat a healthy diet and not eat too much.

    而且還要健康飲食,不要吃得太多。

  • Dr David Sinclair believes certain stresses on the body

    大衛-辛克萊博士認為身體上的某些壓力

  • can actually be good for longevity.

    實際上對長壽有好處。

  • If you do the things that trick the body into thinking

    如果你做那些欺騙身體的事情,讓他們認為

  • times could be tough - short bouts of skipping meals,

    時代可能很艱難--短時的不吃飯。

  • so hunger, fasting, but also losing your breath.

    所以飢餓、禁食,但也會失去呼吸。

  • So running on a treadmill, doing a lot of heavy weight lifting.

    所以在跑步機上跑步,做了很多重體力活。

  • We also think that these are another way to promote the body's defences.

    我們還認為,這些是促進身體防禦的另一種方式。

  • And the combination of all of those things actually is known

    而所有這些東西的組合實際上是已知的

  • to extend lifespan by keeping people healthier for longer.

    通過使人們更健康地生活,延長壽命。

  • Some biohackers are determined to go further

    一些生物學家決心走得更遠

  • and are willing to trial experimental therapies

    並願意試用實驗性療法的人

  • on their own bodies.

    在他們自己的身體上。

  • I decided that I wanted to try every extreme intervention I could -

    我決定,我想嘗試每一種可能的極端干預措施------。

  • the stuff that billionaires are doing,

    億萬富翁們正在做的事情。

  • so that I could write about it and so that I could benefit from it.

    這樣我就可以寫下它,這樣我就可以從中受益。

  • I've had my bone marrow taken out, spun down to get stem cells

    我的骨髓已被取出,旋轉後得到了幹細胞。

  • and reintroduced the stem cells throughout my body.

    並將幹細胞重新引入我的整個身體。

  • There's 150 supplements a day that are part of my regime

    每天有150種補充劑,是我制度的一部分

  • but no-one really needs to do that.

    但沒有人真的需要這樣做。

  • I am a guinea pig to see which ones work

    我是一隻小白鼠,看看哪些是有效的。

  • and I'm constantly experimenting.

    而且我在不斷地進行試驗。

  • There are different degrees of how far people want to go

    人們想走多遠,有不同的程度

  • to slow down their ageing process.

    以延緩其衰老過程。

  • The most advanced I've ever seen,

    是我見過的最先進的。

  • if you want to call it advanced, was there are a few people

    如果你想稱其為先進,有幾個人

  • that have tried reprogramming their body with gene therapy

    嘗試過用基因療法重新規劃身體的人

  • and giving themselves hormones that are delivered by DNA.

    並給自己提供由DNA傳遞的荷爾蒙。

  • To me, that's a risk. I definitely wouldn't go there

    對我來說,那是一種風險。我肯定不會去那裡

  • because these effects are irreversible,

    因為這些影響是不可逆的。

  • and if there was a cancer-causing issue,

    以及是否存在致癌問題。

  • then, really, you're not going to live longer, right?

    那麼,真的,你不會活得更久,對嗎?

  • There is scepticism among many in the mainstream scientific community

    主流科學界的許多人對此持懷疑態度

  • around the role that biohackers can play

    圍繞生物入侵者可以發揮的作用

  • in better understanding our biology.

    在更好地瞭解我們的生物學。

  • Do the risks of this self-experimentation

    這種自我實驗的風險是否

  • outweigh the potential rewards

    超過了潛在的回報

  • or is there a middle ground that could help to push

    還是有一箇中間地帶,可以幫助推動

  • the boundaries of optimising our health?

    優化我們的健康的界限是什麼?

  • The idea of allowing for...

    允許...的想法。

  • ..more use of experimental therapy under informed consent

    ...在知情同意的情況下更多地使用實驗性療法

  • in a way that all data must be shared

    以所有數據必須共享的方式

  • so that we as a community can learn from it,

    是以,我們作為一個社區可以從中學習。

  • I think that's a really exciting idea.

    我認為這是一個非常令人興奮的想法。

  • Biohacking has become a global movement and we are out there

    生物黑客已經成為一場全球運動,我們在外面

  • asking the hard questions and doing the things

    問困難的問題,做困難的事情

  • that a lot of scientists would like to do

    很多科學家想做的是

  • but they're not allowed to do,

    但他們不被允許這樣做。

  • because we still have autonomy over our own bodies.

    因為我們對自己的身體仍有自主權。

  • And when we talk about our results, when we share them online,

    而當我們談論我們的成果時,當我們在網上分享它們時。

  • scientists see them and go, "Interesting",

    科學家們看到他們就會說:"有意思"。

  • and then that provides fuel for studies.

    然後這為研究提供了燃料。

  • The problem becomes when people start doing things

    當人們開始做事情時,問題就變成了

  • which are not evidence based.

    這些都是沒有證據的。

  • You know, for which the information really just isn't out there.

    你知道,其中的資訊真的就是不存在的。

  • Then I think obviously, you know, as with anything else,

    然後我想,顯然,你知道,和其他事情一樣。

  • it can get dangerous.

    它可以變得很危險。

  • If you don't have the information on which to base a decision

    如果你沒有資訊作為決定的基礎

  • to do something but you go ahead and do it, I mean,

    我的意思是,如果你想做一件事,但你卻去做了。

  • that's risky by definition.

    根據定義,這是有風險的。

  • I think somewhere in between there is a happy intermediate.

    我認為在這兩者之間,有一個快樂的中間地帶。

  • I'm a scientist so I like to see what happens to my body

    我是一個科學家,所以我喜歡看我的身體發生了什麼。

  • when I do X, Y or Z, but of course I'm very careful.

    當我做X、Y或Z時,當然我非常小心。

  • I measure what happens

    我衡量所發生的事情

  • and make sure that I'm hopefully not doing myself any harm.

    並確保我有希望不對自己造成任何傷害。

  • Many of those trying to hack the ageing process

    許多試圖破解老齡化進程的人

  • are also interested in trying to optimise their immune systems.

    也對試圖優化他們的免疫系統感興趣。

  • In fact, there are biohackers experimenting with procedures

    事實上,有一些生物黑客在實驗過程中

  • such as faecal transplants - taking someone else's poo as a medicine

    如糞便移植--將別人的糞便作為藥物服用。

  • in an attempt to cure a range of ills.

    試圖治療一系列的疾病。

  • Though less extreme, supermarkets and pharmacy shelves

    雖然不那麼極端,但超市和藥店的貨架上

  • are heaving with so-called immune boosting pills and supplements.

    所謂的提高免疫力的藥丸和補充劑層出不窮。

  • But is it even possible to alter how the body responds to disease

    但是,是否有可能改變身體對疾病的反應方式呢?

  • through consuming someone else's poo or by eating a blueberry pill?

    是通過食用別人的便便還是通過吃藍莓丸?

  • And what are the risks?

    那麼風險是什麼呢?

  • The immune system is part of an interconnected system

    免疫系統是一個相互聯繫的系統的一部分

  • running all the way through our body, involving all our tissues,

    一直貫穿我們的身體,涉及我們所有的組織。

  • from our skin all the way through to our toes.

    從我們的皮膚一直到我們的腳趾。

  • And in fact, the gut has one of the largest resident populations

    而事實上,該腸道擁有最大的常駐人口之一

  • of immune cells in our body.

    我們身體裡的免疫細胞的。

  • Most of the body's immune cells are found in the lining

    人體的大部分免疫細胞都存在於內膜中

  • of the intestine, and the microbes in our gut play a crucial role

    腸道中的微生物在我們的腸道中起著至關重要的作用。

  • in keeping those immune cells of our body healthy.

    在保持我們身體的那些免疫細胞的健康。

  • They do that by providing the key chemical signals

    它們通過提供關鍵的化學信號來做到這一點

  • that they get once they digest the good foods that we eat.

    一旦他們消化了我們吃的好食物,他們就會得到。

  • So a healthy gut microbiome is obviously crucial

    是以,一個健康的腸道微生物組顯然是至關重要的

  • to a healthy immune system.

    對一個健康的免疫系統。

  • The immune system is considered to be an organ, but unlike every

    免疫系統被認為是一個器官,但不同於每個