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  • What if you could live forever?

    如果你能長生不老呢?

  • Okay, maybe not forever, but would you take 150 years?

    好吧,也許不是永遠,但你會接受150年嗎?

  • A new study is shedding light on how we age...

    一項新的研究揭示了我們是如何衰老的。

  • and may even show us a way to push the limits on human lifespan.

    甚至可能向我們展示一種突破人類壽命極限的方法。

  • So, not to get all metaphysical, but what is age, anyway?

    所以,不是要搞什麼形而上學,但年齡到底是什麼?

  • Let’s start by talking about the age were most familiar with: chronological age.

    讓我們先來談談我們最熟悉的年齡:按時間順序的年齡。

  • You know, the one that’s marked on the calendar as your birthday.

    你知道的,就是在日曆上標明你的生日的那個。

  • But this isn’t the best way to gauge your health.

    但這並不是衡量你健康狀況的最佳方式。

  • If you want to find out what toll all that mileage has taken on your body, you need to know your biological age.

    如果你想知道所有這些里程對你的身體造成了什麼影響,你需要知道你的生理年齡。

  • Biological age describes the accumulated damage to your cells

    生物年齡描述了對你的細胞的累積損害

  • caused by genetics and factors like pollution, disease, and chronic lack of sleep,

    由遺傳和汙染、疾病和長期缺乏睡眠等因素造成。

  • as well as the natural decline of cells over time.

    以及隨著時間的推移,細胞的自然衰退。

  • As age increases, DNA accumulates damage, mitochondria break down, and the telomeres at the ends of our chromosomes shorten.

    隨著年齡的增長,DNA積累了損傷,線粒體分解,我們染色體末端的端粒縮短了。

  • This functional decline causes our organs to deteriorate,

    這種功能衰退導致我們的器官惡化。

  • increasing our biological age as a result.

    是以,增加了我們的生物年齡。

  • Until recently, scientists thought the process was irreversible.

    直到最近,科學家們認為這個過程是不可逆的。

  • But within the last couple decades, scientists are learning that cells can revive through a process known asanastasis,”

    但在過去的幾十年裡,科學家們正在瞭解到,細胞可以通過一種被稱為 "吻合 "的過程而恢復活力。

  • Greek forrising to life.”

    希臘語的意思是 "上升到生命"。

  • In a breakthrough study in 2008, a group of biologists conducted an experiment

    在2008年的一項突破性研究中,一組生物學家進行了一項實驗

  • where they put human cancer cells in ethanol to initiate cell death.

    他們將人類癌細胞放在乙醇中以啟動細胞死亡。

  • When the cells were removed from the toxin and put in a fresh petri dish,

    當細胞被從毒素中取出並放在一個新的培養皿中。

  • they came back to life! Which is huge!

    他們又活過來了!這是很巨大的!

  • Then, in 2019, a group of scientists from Yale gained worldwide attention when they briefly revived the cellular function in brains of pigs

    然後,在2019年,來自耶魯大學的一組科學家獲得了全世界的關注,他們短暫地恢復了豬的大腦的細胞功能

  • just four hours after they passed.

    在他們通過後僅四個小時。

  • But why do this?!

    但為什麼要這樣做呢?

  • Well, experiments like these could help us better understand how cells regenerate,

    那麼,像這樣的實驗可以幫助我們更好地瞭解細胞如何再生。

  • and maybe one day, even extend human lifespan.

    也許有一天,甚至可以延長人類的壽命。

  • But before we do that, we first need to know what those lifespan limits are.

    但在這之前,我們首先需要知道這些壽命限制是什麼。

  • To explore that question, a team of researchers in 2021 used a standard blood test to measurewear and tearon the body.

    為了探索這個問題,2021年的一個研究小組使用一種標準的血液測試來測量身體的 "磨損"。

  • They collected data from more than 500,000 people of all ages.

    他們收集了超過50萬名不同年齡段的人的數據。

  • But instead of looking at individual data points associated with aging,

    但不是看與衰老相關的單個數據點。

  • they combined them into a single number called the dynamic organism state indicator, or DOSI for short.

    他們把它們合併成一個數字,稱為動態生物體狀態指標,或簡稱DOSI。

  • A person’s DOSI value changes over time depending on how their body responds to stress.

    一個人的DOSI值隨著時間的推移而變化,取決於他們的身體對壓力的反應。

  • When a person gets sick or injured, their DOSI value goes up.

    當一個人生病或受傷時,其DOSI值會上升。

  • The length of time that it takes for them to recoverand their DOSI to return to normalis what’s known as resilience.

    他們恢復和DOSI恢復正常所需的時間長度就是所謂的復原力。

  • Unsurprisingly, the researchers found that resilience decreased steadily with age.

    不出所料,研究人員發現,隨著年齡的增長,復原力穩步下降。

  • This explains why taking a tumble at age 20 is no big deal, but that same fall at 90 would be a lot harder to get up from.

    這就解釋了為什麼20歲時摔一跤沒什麼大不了的,但90歲時同樣摔一跤就很難爬起來了。

  • People’s physical activity over time was also analyzed, and the data showed a decrease in recovery rates as people aged.

    還分析了人們隨著時間推移的體育活動,數據顯示,隨著人們年齡的增長,康復率也在下降。

  • This matched the decline in resilience measured by the DOSI data,

    這與DOSI數據所衡量的復原力下降相吻合。

  • which confirmed the results were telling us something important about how people age.

    這證實了這些結果正在告訴我們一些關於人們如何變老的重要資訊。

  • What the team found was a trend of declining resilience over time.

    研究小組發現,隨著時間的推移,復原力有下降的趨勢。

  • Let’s say youre perfectly healthy and do everythingright”—

    假設你非常健康,並且做了所有 "正確 "的事情--

  • if you were to hit somewhere between 120 and 150 years old, your resiliency would putter out...

    如果你的年齡在120歲到150歲之間,你的抗壓能力就會下降。

  • and get to a point where your recovery time is so long you don’t recover at all.

    並達到一個點,即你的恢復時間如此之長,你根本就沒有恢復。

  • The TL;DR: even if youre living your best life, according to this study, you won’t make it past 150.

    TL;DR:根據這項研究,即使你過著你最好的生活,你也不會超過150歲。

  • But here’s the upside.

    但這裡有一個好處。

  • If we treat the underlying causes of resilience loss, we could develop life-extending treatments

    如果我們治療復原力喪失的根本原因,我們可以開發延長生命的治療方法

  • that can one day help us live beyond the known limits.

    有一天能幫助我們超越已知極限的生活。

  • And while increasing our lifespan sounds nice,

    而且,雖然增加我們的壽命聽起來不錯。

  • if were able to boost resilience, we have the potential to increase our healthspan too.

    如果我們能夠提高復原力,我們也有可能增加我們的健康期。

  • Which helps us gain more healthy years alive, and that sounds like a life better lived to me.

    這有助於我們獲得更多健康的生存年限,而這在我看來是一種更好的生活。

  • Do you know any 100-year-olds?

    你認識任何100歲的人嗎?

  • Projections suggest there will be 3.7 million centenarians across the globe by 2050.

    預測表明,到2050年,全球將有370萬名百歲老人。

  • If you want to know about one way to live longer with your telomeres,

    如果你想知道一個讓你的端粒活得更長的方法。

  • check out this video from Maren!

    請看馬倫的這段視頻!

  • Don’t forget to subscribe and keeping coming back to Seeker.

    不要忘了訂閱並繼續回到Seeker。

  • Thanks for watching.

    謝謝你的觀看。

What if you could live forever?

如果你能長生不老呢?

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B1 中級 中文 年齡 細胞 恢復 壽命 研究 端粒

我們能活多久?我們可能終於知道答案了 (How Long Can We Live? We May Finally Know the Answer)

  • 26 1
    Summer 發佈於 2021 年 10 月 11 日
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