Name: 冠状病毒如何影响我们的身体| covid 19解释（How Does Coronavirus Affect Our Body | COVID 19 Explained）
Uploaded: 2021-05-23T06:17:27.000Z
Duration: 5 min 20 s
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關係子句

Coronaviruses are a large family of viruses that are known to cause illness ranging from

the common cold to more severe diseases such as Middle East Respiratory Syndrome and Severe

A novel coronavirus or the SARS CoV-2 is a new strain of coronavirus that has not been

Coronavirus spreads from person to person through small air droplets.

Let us say a person with Covid-19 sneezes or exhales in front of you and you inhale

the viral particles coming out of his mouth.

The virus will then travel to the respiratory system.

Epithelial cells of your bronchi which are the main airways in your lungs, bronchiole

, the smaller passageways and most important the tiny air sacs at the end called the alveoli,

Epithelial Cells are like the safety shields of the body, forming a covering of all the

Unfortunately, they are the prime cellular targets of the novel coronavirus because of

the ACE-2 receptors which acts as the entry point.

The virus enters the cell using the spike protein on its surface that binds on a receptor

Viruses have their own genetic code but they lack the machinery to copy their DNA.

So once inside like a Trojan horse, the virus then hijacks and transforms the cell into

The infected cells now serves the virus, synthesizing thousands and thousands of viral proteins

and assembling them, which are later released to enslave more cells and the process continues.

As the infected cells die, they release proteins called Cytokines and Damage-associated molecular

Cytokines are like messenger proteins which acts as a signal to activate the immune system.

Macrophages, one of the most specialised cells of the immune system gets activated.

The macrophages then begin to secrete inflammatory cytokines which results into acute inflammation

To be specific, they release, IL-1, IL-6, IL-8, TNF alpha and IFN gamma.

These cytokines migrate to the capillaries that line the alveoli.

Capillaries are the smallest blood vessels having an endothelial lining comprised of

The inflammatory cytokines increase the spaces between endothelial cells causing the capillaries

As the fluid from the capillaries, starts accumulating inside the alveoli it becomes

The inability to get enough oxygen into the lungs raises the risk for developing hypoxemia,

Also carbon dioxide will start accumulating inside which is called as respiratory acidosis.

As there is increase in the secretion of cytokines, it will induce the expression of a very important

molecule on the endothelial lining of blood vessels, called Vascular cell adhesion protein.

This acts as a magnet, it attracts neutrophils to the site of the injury, inside the alveoli.

Neutrophils are white blood cells whose main function is to kill and clean out the invading

They kill the virus by secreting proteases and reactive oxygen species, but it comes

with a price, which is the damage of the tissue itself.

The cycle will repeat leading to more inflammation and fluid accumulation.

Type 1 alveolar cells, which are involved in the process of gas exchange between the

Type 2 alveolar cells, which are responsible for making the alveoli open, also gets damaged.

As a result alveoli will collapse which will further contribute to hypoxemia.

Additionally, the cytokines secreted by the macrophage will result in the microscopic

clotting of platelets and red blood cells called as microthrombus or the blood clot.

This will lead to more hypoxemia and complete lung failure.

As all these cytokines are secreted into the system circulation, they will have a very

bad effect causing abnormal blood clotting.

Blood clots starts forming throughout the body, blocking small blood vessels.

This is known as Disseminated intravascular coagulation, which is a serious disorder.

So it all began with a nasty cold and a viral pneumonia, from acute respiratory distress

syndrome it progressed to pulmonary embolism and then ultimately led to multi organ failure

It isn't the virus that kills you, but the way your body reacts or fails to react against

There is no 100 percent effective treatment as of yet, but we don't need to panic as

Remember 94 percent of the patients recover from it despite the type of symptoms they

Thoroughly wash your hands with alcohol-based hand rubs or soaps, avoid any physical contact

and stay away from crowds and if you have any symptoms remain calm and contact your

It is really not the end of the world, we just need to break the chain.

Don't you all think our so body is amazing, constantly fighting off infection and disease?

Comment below your thoughts and subscribe for more such wonderful videos.

Thank you for watching, Stay happy Stay Curious.