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  • the virus mutates.

  • Theo Call CDC.

  • My name is Brian Amon.

  • Brian is an Ecologist for the CDC, specializing in infectious diseases.

  • Today I'm breaking down clips from movies and television about pandemics.

  • I'd like to go on record that I love all these movies I don't want to come across is not a fan, because I am a small town outbreak from the movie outbreak.

  • Hold it there now, great chief of police this'll One has so many flies.

  • You see people shaking hands and that doesn't occur in an outbreak area.

  • If there is some kind of a greeting, it's usually elbow to elbow thing.

  • The P P E personal protective equipment is reasonably accurate.

  • We don't go into a place wearing helmets and has Matt suits like that.

  • But the papers, air purifying respirators that they have on their waists are papers that we have used in the past, and the whole point of the powered air is that you have positive pressure inside the head cover.

  • It's pushing air out and nothing can come in.

  • They go from this right here with a full HAZ mat suit and helmet.

  • Two guys with surgical masks you notice that she's not wearing any eye protection.

  • And the guy directly behind her is so one of the little details that if this were truly a feel virus outbreak on this was an isolation ward, they would all have a face shield or eye protection.

  • Some gloves, some others without gloves.

  • It's total chaos.

  • It's a mess.

  • That's pure Hollywood fiction.

  • Apparently, they all got it in the movies.

  • Smallpox E R.

  • When did the rash started?

  • Three days ago.

  • A private room.

  • Could you take Adam?

  • Follow me quickly.

  • What is it?

  • It's just a precaution.

  • Excuse me.

  • Coming through here.

  • It's a case of smallpox.

  • I don't think this is a tad on the far fetched side because smallpox was eradicated in 1980.

  • If a vaccine for now, the CDC should have stuff.

  • All the smallpox that exist in the world are in freezers and really secure labs.

  • Smallpox has been eradicated.

  • The Russians had some on ice.

  • If a terrorist group Guettel and for this to actually have happened, there would have to have been some kind of a very, very serious breach in security.

  • Damn, I should have called in sick.

  • So we're gonna look at a couple of scenes from contagion.

  • And here's where they explain the spread of the virus.

  • Here is a model of the virus and how it attaches to its host.

  • The blue, his virus and the gold is human, and the red is the viral attachment protein, and the green is its receptor.

  • In the human cells it is available.

  • This computer software isn't is able to form sort of, ah, three dimensional image of the virus itself, and they can identify through sequencing which parts of the virus are the receptors where it binds to the human cell.

  • Which parts are coding for certain proteins that cause illness or replication.

  • We've sequenced the virus and determine its origin, and we've modeled the way it enters the cells of the lung and the brain very accurate in terms of being able to pinpoint certain areas of the genome that will have certain effects on the human or on the virus or even the cell that it's infecting.

  • The virus contains both bat and pig sequences in the bottom.

  • Right here you can see the crossover pig that yeah, I haven't heard the term crossover.

  • When the virus leaves the host and enters a new organism that's not a host.

  • It's called spillover.

  • As the spillover events occur and with the multiple times this virus is replicating, they're looking at these mutations as this thing has been going along.

  • That's actually something they could do.

  • Animals spreading disease contagion Very accurate, especially the not hand washing thing.

  • There was an Ebola Reston outbreak in the Philippines at a pig farm.

  • We now have evidence that bats are a possible hosts for Reston.

  • Virus flew to the big farm, and then it was found in the pigs in a sample that was shipped to Plum Island.

  • Outbreak has a ton of problems.

  • Let's take a look at the scene with the Monkey Monkey deserves an Oscar.

  • I don't know where to begin.

  • What can I talk about?

  • The fact that that's a South American monkey that they caught in Africa?

  • Well, it's something At least enough part of my job at the CDC is to catch animals, take samples and test them for viruses.

  • The monkey is a capuchin monkey not found in Africa.

  • It would be some other green monkey, like a vervet or something else like that.

  • We wouldn't use a live person as bait, let alone a child.

  • We actually study reservoir ecology.

  • Know their habits?

  • No, there have a tat on know how to catch them?

  • You know, a monkey could technically bite someone and have virus in the saliva.

  • But generally speaking there, so sick, they just kind of lay there and die.

  • Just go see from contagion.

  • They really got it right here.

  • They did not virus.

  • Choosing the host World War Z, he's infecting himself with another pathogen in hopes that this zombie would pass him by or the virus in the zombie would pass him by e.

  • I like the idea.

  • It gets to essentially the goal of a virus.

  • It wants to find a host that it can continue to replicate its genetic material indefinitely.

  • That's not the question we're really asking, is it?

  • It's fiction, of course, because the virus isn't going to smell if a guy sick be able to tell if this guy has cancer and therefore I don't want to infect that it can't choose Global pandemic and dawn of the Planet of the Apes.

  • Source of the virus was traced back to drug testing done at Gen.

  • Sys Laboratories in San Francisco.

  • Patient Showing signs of what's being ducked The simian flu.

  • The CDC is projecting a fatality toll ranging from five million to as many as 100 and 50 million in the next 6 to 8.

  • Theoretically, that's how things will happen.

  • Those red lines look kind of like, you know, air travel pathways and then having interactions with individuals within an airport, you can't avoid some type of personal space invasion.

  • It's a very plausible scenario.

  • Now known as patient Zero was accidentally exposed to retrovirus LZ 1 30 In this clip, they say Patient zero.

  • And that's not something that we typically used in my field.

  • We tend to use what we call an index patient, the individual that has first been identified to have whatever virus it is or disease caused by whatever virus it is.

  • This clip is about virus mutation from the television show House on Infant Picks up a regular old measles virus gets a rash, is extremely uncomfortable, has a wicked fever, but he lives well.

  • The animation is not extremely accurate.

  • Why do people like me?

  • Because the measles virus is an RN, a virus, and that's a piece of DNA.

  • Could we get off my screwups and focus on theirs on So every 1,000,000 or so times the virus mutates?

  • This explosion is not accurate again.

  • Why are we getting hung up on what I did?

  • What happens is just sort of on error in the copying of the nucleotide bases.

  • Instead of Dan having a fever and a rash, the virus travels to his brain and hides for 16 years.

  • Some acute sclerosing pan encephalitis.

  • Dawson's disease is an actual disease, and it is basic sort of a leftover from having a measles virus infection.

  • So that part is true.

  • Sick brain zombie infection.

  • The walking dead by scan forward to the first event, scanning first.

  • There's no artificial intelligence at the CDC.

  • There are auditoriums at the CDC, but they don't look like this.

  • The brain goes into shutdown, then the major organs.

  • It invades the brain like meningitis.

  • Meningitis is more the condition when here, they're making it seem like it's some sort of a pathogen scan to the second event.

  • I've never used the word event, just a shell driven by mine in severe accidents.

  • I would imagine that that's possibility.

  • I think technically, you you'd probably be declared brain dead.

  • What is that?

  • There'd be some electrical activity there.

  • I don't think you could see it like that.

  • What was that?

  • This looks like Pierce CG Item E.

  • We protected the public from very nasty stuff.

  • Infection in the hospital in the movie outbreak.

  • Dr.

  • Daniels?

  • Yeah.

  • There's something I think you should see.

  • This way.

  • The patient was admitted a week ago after a car accident.

  • He's had no contact with anyone in isolation.

  • Stop there because he just now had contact with that individual in isolation.

  • Truly, this guy should know better.

  • The guy pokes his head into the isolation Ward says Doctor pulls the guy out.

  • They walked down a clean hallway directly into a patient's room with Ebola outbreaks.

  • It would be an entire disinfection process.

  • Before you even came out of that.

  • Probably get sprayed down some sort of a disinfectant.

  • Take all of the peopie off, possibly even shower, depending on where they were by doing this, they just walked in with filthy pp and potentially contaminated everything in the hallway that they just walked out.

  • That would never happen.

  • It's everyone if you're dealing with the virus.

  • That's similar to one that's already known and you know how it's transmitted.

  • There would be a lot of things to go check before you just say it's airborne.

  • I would be very suspicious.

  • Protective gear in pandemic So you see what's out there Lately, I have a rational fear of dying.

  • This goes up and over field.

  • This is obviously the military and not CDC.

  • But the personal protective equipment is similar to what we use.

  • We have cover alls as well.

  • They're tied back.

  • They're impervious to water and other fluids.

  • And that face.

  • She'll keeps you from sticking your dirty fingers in your eye or in your ear.

  • You know, whatever the case may be, this looks similar to what we wear in the field.

  • And now let's take a look at E.

  • T.

  • Elliott thinks it's thoughts.

  • No, Elliot Elliot fears his feelings.

  • The part where they decontaminate before coming in doesn't make a tremendous amount of sense.

  • You want to decontaminate coming out on dive.

  • I've never bean decontaminated with fog.

  • It's usually a chemical shower to make sure that you get ur decontaminated, get more information.

  • Thes hoses would technically be connected to some sort of a fan that would draw air through a filter and put clean air into their hoods.

  • I don't see the hoses connected to anything, not a respirator or anything you can imagine.

  • I'm not saying it's riel.

  • There's no cover up an alien landing on the Earth with its own set of viruses.

  • That doesn't bother it.

  • That that could just, you know, reek havoc on a community.

  • I would be there in a heartbeat because that would be the coolest thing ever.

  • Just imagine what kind of neat viruses you could find in an alien.

  • You might even get the name him.

  • That's how cool that would be.

  • The plague in house.

  • That's Aladdin.

  • Call CDC, tell him what he had.

  • A patient with the plague.

  • Yeah, I mean, there's cases of plague, most of bubonic throughout the Southwest.

  • But he's in there knowing this patient has the plague, and he takes out a syringe that's been in the room with the patient, and he pulls the cap off with his mouth.

  • And then he withdraws a sample and hands the sharp to ah colleague, which is something you don't do the needle or scissors or pointing forceps, even broken glass We call sharps, and typically in the work that we do in the labs, Sharps is handled by pretty much just one person.

  • You'd never see a, ah, hand off of a needle like that.

  • So that part was bad.

  • You know where to go, where to go.

  • Here's another zombie movie.

  • World War Z.

  • Absolutely getting blood in your mouth as a way to get an infectious disease.

  • Bodily fluids coming into contact with mucus membranes.

  • You notice that he stood on the edge.

  • Hey knows that he's been exposed, and a lot of people that work with these viruses myself included.

  • If we have an exposure, we're not going to keep it quiet.

  • We have a responsibility to the public.

  • Will, Self isolate, will make sure that we're not sick and if we are sick, will go into isolation.

  • We certainly wouldn't stand on the edge of a building waiting to throw ourselves off, but, you know, you get the ideas I got in my mouth.

  • Decontamination in the Andromeda strain way start decontamination and immunisation procedures.

  • Now you will notice a fine point ash on your body.

  • That's completely science fiction, and nobody in their right mind would let themselves get cook to the point where their outer layer of empathy Liam has turned to ash.

  • I mean, that's the definition of, you know, a giant sunburn.

  • We face quite a problem out of this.

  • In fact, the human body, one of the dirtiest things in the known universe.

  • Hard on the taxpayers, isn't it the way we burn up uniforms and a lot of the clips that we've reviewed today.

  • You see this decontamination process occurring before they go into an infectious area or into a lab, and it's always just the opposite for us.

  • Do you want to clean yourself off before you come out into an area where the virus isn't martial law?

  • The crazies, sure, Dr Theo way don't force people into treatment facilities.

  • We try to coax them in there.

  • We don't have any regulatory authority where we can arrest people and throw them in a cage or anything like that.

  • Aside from the separating the people part, temperature is a good way to identify someone with a fever and is a common practice.

  • One of the things that was incorrect here is that they were actually sticking the thermometer probe in the year.

  • That would never happen.

  • You don't touch the individual because you're just transmitting from one person to the next what they use his hand help thermometers.

  • And they pointed at your temple on.

  • They'd hold it a few inches away, and they get a reading that way.

  • That's not correct.

  • She's being wheeled through there, seeing bloody gurneys being passed by.

  • And isolation facilities are typically Maur of, ah, hospital care type of setting.

  • It's it's not gonna be under armed guard.

  • You wouldn't be left.

  • Let your imagination run wild and there would be some explanation as to what's going to happen, how you'll be cared for.

  • It's gonna be all right.

  • We're gonna be okay.

  • Let's look at a similar scene in I am legend.

  • Clear.

  • If there was some way to detect an abnormality that was a symptom of infection in the eye, that that's why they'd be using that they're not touching the individual with the actual scope, although their hands are all over people and it's a giant crowd, no good, no scandal skin organs.

  • This is obviously fiction.

  • After that, we would have done many more scans to make sure that she was, in fact, negative.

  • These kinds of scans, the temperature and the eye thing that you saw in this clip can detect symptoms of infection.

  • They can't really definitively say that you are infected doing There are some mechanisms now that arm or rapid than just your traditional PCR that turn around test results very quickly.

  • But they're not on site kind of things.

  • It's it's requiring some sort of a blood sample that's taken back to a lab, so just simply scanning them can't tell you basically anything other than their feeling.

  • You'll always want to follow up a scan like a temperature with a blood test to identify that that person is either infected with Ebola, Marburg feel virus or it's something else.

  • Zombie by the girl With all the gifts that was quick, you may have got a pretty decent sized dose of virus in whatever infection mechanism you just encountered, but it takes time for the virus to locate the target cell, inject its own aura or d n a into the cell and then disseminate throughout the body.

  • Generally speaking, it doesn't happen in 10 or 15 seconds Theo doctor picks up a shard of glass and start stabbing one of the zombies in the head, presumably getting fluid in the cuts in her hand.

  • And she didn't get infected.

  • You can't have it both ways.

  • Or maybe she's one of those immune people emphatically, not another zombie virus in 28 weeks later, kissing is a great way to get a virus.

  • I mean, there's no question about that, but again, it wouldn't happen that that quickly incubation periods for some viruses can be days, weeks or even months.

  • I love the movie, but it's still it's still faces.

  • Here's more protective gear again in SNL, in our stars to a bola in our everything.

  • No, you wouldn't be able to have a relationship that having to dress that way all the time, that would get old.

  • She wants to have sex.

  • Hey, Ono.

  • Levels of infection pandemic is level two.

  • Hemorrhaging begins Level three patients.

  • I've never seen an isolation ward look like this.

  • There is some level of security, and it's mostly to keep people out.

  • You keep people that are so suspect cases separate from people that are confirmed cases on his level four look at these two come together in love with the 1st 1 to wake up, will kill the other one and not know why.

  • It's not anything like Level one level, too.

  • For the most part, what you've got is a tent or, let's say, a hospital ward that's probably filled up pretty quickly and you're not gonna have the luxury of having that kind of space robot lab in resident evil.

  • At the CDC, there are robotic machines.

  • You'll have things that just it moves in under an it dips and it moves it underneath dips.

  • And that's the robot.

  • Part of it is, we call it the Robot, But it's not, you know, the Robby the robot kind of thing.

  • It's more of an automated extraction machine way.

  • Don't use glass vials in the high containment laboratories for that exact reason, although I suspect that was done intentionally.

  • Blood test from the thing.

  • We're gonna draw a little bit everybody's blood.

  • We're gonna find out who's the thing.

  • We'll do you last.

  • I hate it when my flamethrower doesn't work.

  • There's visible blood tests.

  • Best example is malaria.

  • You can look at a blood sample under a microscope and actually see the parasite infecting the cell toe.

  • Have a reaction like that, though, where the blood jumps out of the Petri dish in runs away.

  • I mean, it's cool, but this is Pierce I If I Theo lab in the hot zone, no one goes into a Level four alone, I'll be standing you head to toe for anything that could lead contaminated particles in.

  • All right, just breathe.

  • Breathe through it.

  • What are you doing?

  • I'm checking your pupils Signs of panic entry into an HCL.

  • If we're talking to people, we usually say the HCL or the high containment lab.

  • If you're panicking like that, putting the suit on, the chances are you would never go inside.

  • You've got a continual flow of fresh air and it's it's not panic inducing welcomes in the hot sun.

  • No, we don't never call it the hot zone.

  • It's the lab, I would like to point out, though they didn't decontaminate going in that part.

  • They got right conclusion, I guess, the idea of a pandemic and really bring out the fear in the panic and people.

  • But they tend to be not nearly as uncontrollable as Hollywood makes it seem a lot of the work that the CDC does is to make sure that disease outbreaks like this don't ever get to the stage of a global pandemic virus is that you've seen in these clips are basically Hollywood fiction, and the real life viruses that are out there are hardly ever, if at all, as fast acting is what you've just seen in these cliffs.

  • Thank you.

the virus mutates.

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