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  • Candida auris is the new superbug on the block you've probably never heard of. This stealthy,

  • drug-resistant yeast can already be found in hospitals worldwide, preying on those with

  • weakened immune systems. The fungus is so prolific that the CDC recently added it to

  • its list of urgent threats. So what exactly is candida auris and how did it fly under

  • the radar to emerge as a global health threat?

  • The feature of Candida auris is not so much the infection that it caused, but the fact

  • that it can spread.

  • And where did it come from? You know, where was it before 2009? That's the million dollar question.

  • Dr Zelazny is right. Candida auris kind of came out of nowhere. Unlike other fungi, this

  • yeast can only be found in people, which has scientists completely stumped. The very first case

  • of C. auris was confirmed when the fungus was isolated from the ear canal of a 70-year-old Japanese woman

  • as recently as 2009 and since then, it's spread rapidly across the globe.

  • Now, you may have heard of Candida, it's a term used for a genus of yeasts that are

  • responsible for the most common fungal infections worldwide. Most healthy adults, like you and

  • me, have a type of candida, called candida albicans, living all over our skin, as well

  • as within our throat and gut. This yeast usually doesn't do any harm, but given the right

  • conditions, it can flourish, and cause opportunistic infections; think athlete's foot, jock itch

  • and thrush. And those types of infections are usually treatable, but that's not the

  • case with C. auris.

  • Most candida auris are resistant to fluconazole, which is

  • a very common antifungal used to treat the candida albicans.

  • Another reason why C. auris poses such a threat is because its symptoms mimic other common

  • candida infections, making it incredibly difficult to diagnose in the first place.

  • Candida auris doesn't have any specific symptoms different from any other Candidas.

  • So it will be fever, if the patient has a sepsis or a blood infection. If the patient

  • has an urinary infection could be itching, going to the bathroom or can

  • be pain.

  • And since it can be easily confused with other yeast infections, special laboratory tests

  • are needed to specifically diagnose C. auris.

  • Only certain labs, like the NIH, that use more advanced technologies like MALDI-TOF

  • mass spectrometry or sequencing, could reliably identify Candida auris.

  • And identifying C. auris quickly is crucial since once the fungus enters the bloodstream,

  • it can be fatal, with a mortality rate between 30 and 60 percent. And that high mortality rate

  • is partly because C. auris preys on the sick. For reasons completely understood by researchers,

  • the fungus is able to spread rapidly in hospitals and nursing homes. It clings to everything

  • from medical equipment to beds, clothing, walls, ceilings, and even window shades, remaining

  • on surfaces for several weeks on end.

  • If you combine spreading from patient to patient, surviving in the hospital environment, even

  • after the patient left, and antifungal resistance, then you have a cocktail that could qualify

  • you as superbug.

  • Oh and if that's not scary enough, C. auris is also resistant to disinfectants. Hospitals

  • are now using specialized cleaning equipment and some have even been forced to take more

  • extreme measures like replacing floorboards and ceiling tiles to completely get rid of

  • the deadly fungus. And to try and stem the ongoing spread of C. auris, scientists are

  • scrambling to try and solve the mystery of its transmission.

  • Yeah, that's another question that people don't know yet. Skin seems to be the site

  • where it leaps. So perhaps transmissions through instrumentation.

  • And since its emergence on the world stage, there have been four types, or clades, of Candida auris

  • identified worldwide: from East Asia, South Asia, South Africa, and South America. So far, roughly

  • 1,000 clinical cases of C. auris in the U.S have been confirmed, and knowing what we know

  • about C. Auris, that number is likely to go up.

  • Candida auris is emerging very quickly. So for those countries, or states within the

  • United States where it's prevalent, I would be concerned because you know when you

  • have transmission of an organism, you want to stop that cycle. You don't want this to continue.

  • Candida auris is new, so we need to make people more aware of it. And CDC is doing that along

  • the state labs. But I don't think everyone knows about it as much as they perhaps know

  • about superbugs, like super bacteria that are resistant to antibiotics.

Candida auris is the new superbug on the block you've probably never heard of. This stealthy,

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迎接正在佔領世界的抗藥性超級細菌的到來 (Meet the Drug-Resistant Superbug That’s Taking Over the World)

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    Summer 發佈於 2021 年 01 月 14 日
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