Name: 迎接正在佔領世界的抗藥性超級細菌的到來 (Meet the Drug-Resistant Superbug That’s Taking Over the World)
Uploaded: 2021-01-14T11:00:17.000Z
Duration: 4 min 25 s
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Candida auris is the new superbug on the block you've probably never heard of. This stealthy,

進階被動語態

drug-resistant yeast can already be found in hospitals worldwide, preying on those with

weakened immune systems. The fungus is so prolific that the CDC recently added it to

its list of urgent threats. So what exactly is candida auris and how did it fly under

the radar to emerge as a global health threat?

The feature of Candida auris is not so much the infection that it caused, but the fact

And where did it come from? You know, where was it before 2009? That's the million dollar question.

Dr Zelazny is right. Candida auris kind of came out of nowhere. Unlike other fungi, this

yeast can only be found in people, which has scientists completely stumped. The very first case

of C. auris was confirmed when the fungus was isolated from the ear canal of a 70-year-old Japanese woman

as recently as 2009 and since then, it's spread rapidly across the globe.

Now, you may have heard of Candida, it's a term used for a genus of yeasts that are

responsible for the most common fungal infections worldwide. Most healthy adults, like you and

me, have a type of candida, called candida albicans, living all over our skin, as well

as within our throat and gut. This yeast usually doesn't do any harm, but given the right

conditions, it can flourish, and cause opportunistic infections; think athlete's foot, jock itch

and thrush. And those types of infections are usually treatable, but that's not the

Most candida auris are resistant to fluconazole, which is

a very common antifungal used to treat the candida albicans.

Another reason why C. auris poses such a threat is because its symptoms mimic other common

candida infections, making it incredibly difficult to diagnose in the first place.

Candida auris doesn't have any specific symptoms different from any other Candidas.

So it will be fever, if the patient has a sepsis or a blood infection. If the patient

has an urinary infection could be itching, going to the bathroom or can

And since it can be easily confused with other yeast infections, special laboratory tests

are needed to specifically diagnose C. auris.

Only certain labs, like the NIH, that use more advanced technologies like MALDI-TOF

mass spectrometry or sequencing, could reliably identify Candida auris.

And identifying C. auris quickly is crucial since once the fungus enters the bloodstream,

it can be fatal, with a mortality rate between 30 and 60 percent. And that high mortality rate

is partly because C. auris preys on the sick. For reasons completely understood by researchers,

the fungus is able to spread rapidly in hospitals and nursing homes. It clings to everything

from medical equipment to beds, clothing, walls, ceilings, and even window shades, remaining

If you combine spreading from patient to patient, surviving in the hospital environment, even

after the patient left, and antifungal resistance, then you have a cocktail that could qualify

Oh and if that's not scary enough, C. auris is also resistant to disinfectants. Hospitals

are now using specialized cleaning equipment and some have even been forced to take more

extreme measures like replacing floorboards and ceiling tiles to completely get rid of

the deadly fungus. And to try and stem the ongoing spread of C. auris, scientists are

scrambling to try and solve the mystery of its transmission.

Yeah, that's another question that people don't know yet. Skin seems to be the site

where it leaps. So perhaps transmissions through instrumentation.

And since its emergence on the world stage, there have been four types, or clades, of Candida auris

identified worldwide: from East Asia, South Asia, South Africa, and South America. So far, roughly

1,000 clinical cases of C. auris in the U.S have been confirmed, and knowing what we know

about C. Auris, that number is likely to go up.

Candida auris is emerging very quickly. So for those countries, or states within the

United States where it's prevalent, I would be concerned because you know when you

have transmission of an organism, you want to stop that cycle. You don't want this to continue.

Candida auris is new, so we need to make people more aware of it. And CDC is doing that along

the state labs. But I don't think everyone knows about it as much as they perhaps know

about superbugs, like super bacteria that are resistant to antibiotics.