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Whether it leaves us feeling stuffed up or sniffling, mucus can make us miserable.
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But despite being a little icky, phlegm gets a bad rap.
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This germ-fighting goo contains cells and compounds that help us power through a cold, and what turns up in our tissues can be a useful clue about the inner workings of our immune systems.
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That's right, it's time for the colorful, chemical secrets of snot.
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When we get sick with a cold or sinus infection, our bodies begin to produce more mucus than normal to double down on the viral or bacterial invaders.
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At this point, the consistency and color of snot also changes, going from healthy and clear to, well, not so clear.
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Think of your snot like a traffic light.
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Yellow or white mucus turns up when you're congested, and a higher concentration of living and dead white blood cells have thickened the discharge.
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These immune cells might be there to battle a cold, so slow down and take it easy.
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If your mucus looks green, that could be due to the presence of a greenish enzyme called myeloperoxidase, which helps produce acids in powerful immune cells called neutrophils.
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With neutrophils hard at work, your body is probably in full "go mode," trying to kick a viral infection.
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Red mucus means stop picking or blowing… but fear not, small amounts of blood in mucus are totally normal and no cause for concern.
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No matter what the color, too much mucus can be annoying or painful - which might bring you to the drug store for relief.
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But what you decide to buy should match your symptoms and their root cause.
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For example, if you're dealing with a runny nose, one possible culprit is histamine: Histamine plays a pivotal role in allergies and other immune responses by increasing blood flow to snot-producing body tissues.
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Fortunately, antihistamine drugs block some histamine from reaching their target mucus-producing cells.
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They can also cut down the production of histamine altogether… all of which helps you quit reaching for the tissue box.
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Or perhaps you're dealing with an arguably more annoying snot problem - congestion.
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If your head is pounding with pressure, decongestants work to reduce blood flow to nasal and sinus tissues that produce mucus, this time by constricting the blood vessels themselves.
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Cutting down on the volume of snot and reducing inflammation should help ease pressure on your nose and sinuses.
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That could clear things out a little bit easier.
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But over reliance on both antihistamines and decongestants can decrease their effectiveness over time, so sometimes, it's best to just rest up and let your immune system do its thing.
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But did you know that under the right conditions, some runny noses have nothing to do with being sick or having allergies.
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If you suddenly feel sniffly standing out at the bus stop, don't blame it on snot.
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That's actually condensation from water in the cold air hitting your warm nostrils.
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So you don't have to feel quite so gross about wiping it on your sleeve - yeah, we see you there Kyle.
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For more snot science, be sure to check out Anna's video at Gross Science.
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She's covering snot 101, what it is, what it does, and everything you could possibly want to know about snot.
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Be sure to subscribe to her channel for videos like why dogs eat their own poop, the vomiting defense of birds, and so much more.
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While we still have you, be sure to thumbs up and subscribe on your way out, and hey, thanks for watching!