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  • Humans have long pursued the Fountain of Youth and with the wide-ranging benefits of reducing disease and enabling a longer, healthier life, reversing the causes of aging is a major focus of much medical research.

    人類不停追求青春及其帶來的各種好處,包括減少疾病發生、活得更久更健康,而逆轉老化的原因一直是醫療研究的重心。

  • Normally, the process of aging in the human body starts at middle age around 45.

    通常人的老化出現在中年約45歲

  • The process and its effects depend on both, the genetic as well as environmental factors.

    老化過程受到基因和環境影響

  • Aging causes some amount of reduction in the rate of human cell multiplication

    老化導致人體細胞增殖速率下降

  • and also causes some of the cells to function inappropriately.

    也造成一些細胞無法正常運作

  • Ageing is considered a one-way street, but researchers at Harvard University have shown that some aspects can be reversed.

    老化被視為不可逆的單行道,但哈佛大學研究指出有些方面是可逆的。

  • Researchers say that they've been able to reverse the aging process in mice,

    研究人員已經能夠倒轉老鼠的老化過程,

  • using a chemical that in one week made two-year-old mice tissue resemble tissue of six-month-old mice.

    他們用化學藥劑在一周內把2歲大老鼠組織變成6個月大,

  • In human years, that's as if a 60-year-old's cells became more like the cells of a 20-year-old.

    以人的年紀來說就是60歲的細胞變成20歲的細胞。

  • The researchers have managed to reverse the effects

    研究人員試著逆轉

  • of aging in mice using an approach that restores communication between a cell's mitochondria and nucleus.

    老化對老鼠的影響藉由修復粒線體和細胞核間的連結。

  • Mitochondria are the power supply within the cell,

    粒線體即"細胞能量工廠",

  • generating the chemical energy required for key biological functions.

    產生的能量是生理機能不可或缺的。

  • When communication breaks down between mitochondria and the nucleus,

    當粒線體和細胞核,

  • which is the cell's control center, the effects of aging accelerate.

    又稱控制中心間的通訊消失,老化會加速

  • The study found that by restoring this molecular communication,

    研究發現藉由修復分子間的通訊,

  • aging could not only be slowed, but could be reversed.

    老化不僅能被減緩,更能被逆轉

  • Responsible for this communication breakdown is a decline of the chemical NAD.

    通訊中斷的原因是NAD(菸鹼醯胺腺嘌呤二核苷酸)減少。

  • This chemical reduces in the body as we age.

    此化學物質會隨年齡逐漸減少。

  • By increasing amounts of a compound used by the cell to produce NAD,

    藉由增加能讓細胞產生NAD的化合物

  • the researchers found that they could quickly repair mitochondrial function.

    研究人員發現他們能快速修復粒線體的功能

  • And that led to the radical reversal in the ageing of the mice.

    因而使老鼠迅速逆轉老化

  • They had more energy, their muscles were as though they'd be exercising

    牠們精神飽滿,牠們的肌肉像是運動後般

  • and it was able to mimic the benefits of diet and exercise just within a week.

    而且可透過飲食與運動在一周內達到相同的好處。

  • Researchers say that the diseases they have come to expect of old age have been drastically reversed in mice.

    研究人員表示他們預期老化帶來的疾病也大幅減少

  • Even the younger mice showed benefits from the compound,

    即使是幼鼠也從化合物得到好處,

  • making them "supercharged" above normal.

    牠們比一般老鼠更能量充沛

  • The researchers say a "magic pill" that reverses ageing is several years away,

    研究人員表示能逆轉老化的神奇藥丸還要等好幾年

  • partially due to the cost of the compound, which would be about $50,000 a day for a human.

    部分是因為人體一天所需的化合物要價5萬美元

  • Reversing aging isn't just to make people live until they are 200 or 300,

    逆轉老化不是讓人活到2百或3百歲

  • the goal is to keep people healthier for longer and keep them from getting diseases of aging.

    而是能維持健康更久且免於老化帶來的疾病

  • Thanks for watching.

    謝謝收看

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    請訂閱更多影片並追蹤我們的臉書動態以及谷歌

Humans have long pursued the Fountain of Youth and with the wide-ranging benefits of reducing disease and enabling a longer, healthier life, reversing the causes of aging is a major focus of much medical research.

人類不停追求青春及其帶來的各種好處,包括減少疾病發生、活得更久更健康,而逆轉老化的原因一直是醫療研究的重心。

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B1 中級 中文 美國腔 老化 粒線體 細胞 老鼠 研究 通訊

老化可以逆轉嗎? (Could Aging Be Reversed?)

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    Precious Annie Liao 發佈於 2015 年 01 月 23 日
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