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Fertilization is the epic story of a single sperm facing incredible odds
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to unite with an egg and form a new human life.
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It is the story of all of us.
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During sexual intercourse, about 300 million sperm enter the vagina.
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Soon afterward, millions of them will either flow out of the vagina,
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or die in its acidic environment.
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However, many survive because of the protective elements
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provided in the fluid surrounding them.
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Next, the sperm must pass through the cervix, an opening into the uterus.
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Usually it remains tightly closed, but here the cervix is open for a few days
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while the woman ovulates.
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The sperm swim through the cervical mucus,
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which has thinned to a more watery consistency for easier passage.
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Once inside the cervix, the sperm continue swimming toward the uterus,
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though millions will die trying to make it through the mucus.
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Some sperm remain behind, caught in the folds of the cervix,
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but they may later continue the journey as a backup to the first group.
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Inside the uterus, muscular uterine contractions
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assist the sperm on their journey toward the egg.
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However, resident cells from the woman's immune system,
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mistaking the sperm for foreign invaders,
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destroy thousands more.
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Next, half the sperm head for the empty fallopian tube,
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while the other half swim toward the tube containing the unfertilized egg.
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Now, only a few thousand remain.
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Inside the fallopian tube, tiny cilia push the egg toward the uterus.
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To continue, the sperm must surge against this motion to reach the egg.
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Some sperm get trapped in the cilia and die.
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During this part of the journey, chemicals in the reproductive tract
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cause the membranes covering the heads of the sperm to change.
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As a result, the sperm become hyperactive, swimming harder and faster toward their destination.
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At long last, the sperm reach the egg.
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Only a few dozen of the original 300 million sperm remain.
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The egg is covered with a layer of cells called the corona radiata.
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The sperm must push through this layer to reach the outer layer of the egg,
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the zona pellucida.
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When sperm reach the zona pellucida, they attach to specialized sperm receptors on the surface,
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which triggers their acrosomes to release digestive enzymes,
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enabling the sperm to burrow into the layer.
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Inside the zona pellucida is a narrow, fluid-filled space just outside the egg cell membrane.
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The first sperm to make contact will fertilize the egg.
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After a perilous journey and against incredible odds, a single sperm attaches to the egg cell
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membrane.
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Within a few minutes, their outer membranes fuse, and the egg pulls the sperm inside.
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This event causes changes in the egg membrane that prevent other sperm from attaching to
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it.
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Next, the egg releases chemicals that push other sperm away from the egg and create an
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impenetrable fertilization membrane.
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As the reaction spreads outward, the zona pellucida hardens, trapping any sperm unlucky
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enough to be caught inside.
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Outside the egg, sperm are no longer able to attach to the zona pellucida.
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Meanwhile, inside the egg, the tightly packed male genetic material spreads out.
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A new membrane forms around the genetic material, creating the male pronucleus.
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Inside, the genetic material reforms into 23 chromosomes.
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The female genetic material, awakened by the fusion of the sperm with the egg, finishes
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dividing, resulting in the female pronucleus, which also contains twenty-three chromosomes.
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As the male and female pronuclei form,
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spiderweb-like threads, called microtubules,
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pull them toward each other.
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The two sets of chromosomes join together, completing the process of fertilization.
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At this moment, a unique genetic code arises, instantly determining gender, hair color,
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eye color and hundreds of other characteristics.
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This new single cell, the zygote, is the beginning of a new human being.
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And now the cilia in the fallopian tube gently sweep the zygote toward the uterus
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where he or she will implant in the rich uterine lining, growing and maturing for the next nine months
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until ready for birth.